EY1920 Year Book

15 14 Intercalated BSc at University of Bristol Unit Credits Research unit 40 Cancer mechanism & therapeutics 20 Developmental genetic & embryonal cancer 20 Immunopathology & applied immunology 20 Medical microbiology 20 Lectures • Learnt basic medical sciences across different fields • Enjoyed learning basic knowledge required for translational research in the future • Most enjoyed Cancer mechanisms and therapeutics because understand the genetics and underlying cell biology, leading to development of novel therapies (eg Direct BH3-only protein activators, glutaminase inhibitors etc) • Did not enjoy Medical Microbiology because they are not very practical Research project • Objective : Finding bacterial from soil which can produce antimicrobials against Staphylococcus aureus • Materials and methods : Culture bacteria from soil, collect the supernatants from broth cultures and introduce supernatants to S. aureus culture. 16S amplicon sequencing and BLAST alignment was used to identify the species. • Results : One strain of bacterium was found to produce antimicrobials. It was identified as a Bacillus species • Conclusion : it is feasible to find antimicrobials-producing bacteria in soil. Further research is required to extract the antimicrobial and determine its mechanism of action. Results Sequence Bacillus wiedmannii strain FSL W8-0169 16S ribosomal RNA, partial sequence Bacillus pacificus strain MCCC 1A06182 16S ribosomal RNA, partial sequence Bacillus mobilis strain MCCC 1A05942 16S ribosomal RNA, partial sequence Bacillus paramycoides strain MCCC 1A04098 16S ribosomal RNA, partial sequence Bacillus paranthracis strain MCCC 1A00395 16S ribosomal RNA, partial sequence Bacillus proteolyticus strain MCCC 1A00365 16S ribosomal RNA, partial sequence MBBS Enrichment Year 2019/20 Chan Ching Him Full Year < IC - Intercalated degree at University of Bristol, UK > Chan Ching Him Chan Ching Yan