MBBS Enrichment Year 2018-19

Intercalation in the University of Bristol - BSc Clinical Sciences By Thomas Tsoi Shui King Conduct research project: Predicting visual prognosis in patients with skull base tumours This study was to determine which measures of visual function predict visual outcome over time, after surgery and after radiotherapy in benign skull base tumour patients. A total number of 116 patients diagnosed with benign tumour located in the skull base which affected the vision pathway were retrospectively recruited from the Bristol Eye Hospital. Regression models were built to predict the change in vision outcome after intervention. Repeated measures ANOVA is used for comparing the mean of vision outcome across 4 time points (pre-op, 3 months post-op, 6 months post op, 12 months post-op). It was suggested that preoperative vision acuity has the highest predictive value among different vision parameters towards the postoperative outcome for skull base tumour. The vision acuity and vision field of the patients receiving surgery or radiotherapy have significant improvement. Mean RNFL thickness has marked deterioration no matter with surgery or without treatment after 6 months. Learn about latest advances in basic and clinical research During the year-long course, it had illustrated qualitative and quantitative research and epidemiological approaches to clinical research, helping me to gain an understanding of the clinical aspects of musculoskeletal disease and how “big data” are managed and utilised to generate research outcomes. My course had also addressed the biochemistry and molecular genetics of disease processes. Understanding the pathways that contribute to aberrant cellular and physiological processes will definitely add to the body of knowledge of the underlying mechanisms of disease, thus enabling identification of drug targets for treating disease or identification of novel biomarkers of disease. It has also introduced the diseases of the nervous system, giving an overview of research into regenerative strategies that are being developed to slow disease progression or to treat neurodegenerative disorders. It covered the basic biology of neurodegenerative disorders, current therapeutic strategies and pre-clinical/clinical applications of experimental research. Tsoi Shui King 167