MBBS Enrichment Year 2018-19

A prospective, observational study to investigate the associations of the gut microbiome with vascular health Why does the Gut microbiome matter? What are being done? : 1. Body parameters (BMI, waist-hip ratio) 2. Vascular ultrasounds (FMD, IMT) 2. Arterial stiffness 3. Ankle-brachial index 4. Fibroscan 5. Physical activity 6. Sleep-wake information 7. Diet questionnaires 8. Blood tests (Glu, lipid profile) 9. Spot urine for Na + 10. Gut microbiome genomic analysis Diet Physical activity Living environment Sleep Stress Ethnicity Vascular function Cognitive function Faecal Sampling DNA Extraction Shot-gun Metagenomics Genomic Analysis Procedures: The Imaging Studies: Flow mediated dilatation of brachial artery (FMD) Carotid Intima Thickness (IMT) Fibroscan Pijarnvanit Kong Kam Tim Siriphong 140