B. Representative Research Publications 2021-2022 38 First or Corresponding Authored Publications in 2021-2022 *Corresponding Author (1) Zhang X, Guo PY, Lin C, Li F, Nguyen A, Sakata R, Higashita R, Okamoto K, Yu M, Kato C, Aihara M, Aung T, Lin S, *Leung CKS. Assessment of Iris Trabecular Contact in Eyes with Gonioscopic Angle Closure. Ophthalmology. 2022 (In Revision).ᅠ (2) *Leung CKS, Guo PY, Lam AKN. Retinal Nerve Fiber Layer Optical Texture Analysis (ROTA): Involvement of the Papillomacular Bundle and Papillofoveal Bundle in Early Glaucoma. Ophthalmology. 2022 (In Press) (3) *Leung CKS, Lam AKN, Weinreb RN, Garway-Heath DF, Yu M, Chiu V, Wan K, Wong M, Wu K, Cheung CY, Lin C, Chan C, Chan NC, Kam KW, Lai G. Retinal nerve fiber layer Optical Texture Analysis (ROTA) – A new paradigm for diagnostic evaluation of optic neuropathy. Nature Biomedical Engineering. 2022;6:593-604. (4) *Leung CKS, Ren ST, Chan PPM, Wan KHN, Kam AKW, Lai GWK, Chiu VSM, Ko MWL, Yiu CKF, Yu MCY. Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial. Trials. 2022;23:45. (5) Wong MOM, Lai IS, Chan PP, Chan NC, Chan AY, Lai GW, Chiu VS, *Leung CKS. E�cacy and safety of selective laser trabeculoplasty and pa�ern scanning laser trabeculoplasty: A randomised clinical trial. Br J Ophthalmol. 2021;105:514-520. (6) Mak HK, *Leung CKS. MicroRNA-based therapeutics for optic neuropathy: opportunities and challenges. Neural Regen Res. 2021;16:1996-1997 (Invited Editorial). (7) Goit RK, Taylor AW, *Lo ACY. Anti-inflammatory α-Melanocyte-Stimulating Hormone Protects Retina A�er Ischemia/ Reperfusion Injury in Type I Diabetes. Front Neurosci. 2022 Feb 25;16:799739. (8) Goit RK, Taylor AW, *Lo ACY. The central melanocortin system as a treatment target for obesity and diabetes: A brief overview. Eur J Pharmacol. 2022 Jun 5;924:174956. (9) Hu T, *Lo ACY. Collagen-Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences. Polymers (Basel). 2021 Jun 2;13(11):1852. (10) Tang LHC, Fung FKC, Lai AKW, Wong IYH, Shih KC, *Lo ACY. Autophagic Upregulation Is Cytoprotective in Ischemia/ Reperfusion-Injured Retina and Retinal Progenitor Cells. Int J Mol Sci. 2021 Aug 6;22(16):8446. (11) Tsang JKW, Wolf SA, Pompoes IM, Joussen AM, Lam WC, Yang D, *Lo ACY. Potential E�ects of Nutraceuticals in Retinopathy of Prematurity. Life (Basel). 2021 Jan 22;11(2):79. (12) Yang M, So KF, Lam WC, *Lo ACY. Cell Ferroptosis: New Mechanism and New Hope for Retinitis Pigmentosa. Cells. 2021 Aug 21;10(8):2153. (13) Zhou T, Lee A, *Lo ACY, Kwok JSWJ. Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic Strategies. Front Pharmacol. 2022 Feb 23;13:816062. (14) Yang M, Tsui MG, Tsang JKW, Goit RK, Yao KM, So KF, Lam WC, *Lo ACY. Involvement of FSP1-CoQ10-NADH and GSHGPx-4 pathways in retinal pigment epithelium ferroptosis. Cell Death Dis. 2022 May 18;13(5):468. (15) *Lo ACY, Yang M. Lycium barbarum polysaccharides and ferroptosis: jumping into the era of novel regulated cell death. Neural Regen Res. 2022 Jul;17(7):1473-1474. 11 HKU Eye Center Inaugural Report The University of Hong Kong