Department of Medicine

http://www.medic.hku.hk
Why do brain cells die in Parkinson's disease, and how can we slow or prevent them from dying?
What biochemical markers predict lupus patients will develop kidney complications?
Why do people who have never smoked still get lung cancer?
What is the impact of intermittent hypoxia (as seen in sleep apnea) on cardiovascular or metabolic function?

Major Research Areas

Cardiology:
Angiogenesis and cell repair – cell therapy to create new vessels and myocardium in humans and large animals.

Cardiac arrhythmia – innovative energy sources for catheter ablation, transvenous defibrillation and implantable device for treatment of atrial fibrillation; patch clamp study on ionic channels in atrial fibrillation and heart failure related arrhythmogenic potential.

Cardiac pacing – new developments in pacing therapy for treatment of heart failure and cardiac arrhythmia.

Cardiac muscle engineering – gene knock-out study on differentiation of myocytes into cardiac myocytes.

Coronary heart disease – prevention and percutaneous revascularisation of stable ischaemic syndromes; epidemiology and treatment of acute coronary syndromes, and platelet resistance.

Heart failure – hormonal changes and animal models of heart failure; cardiac resynchronisation therapy.

Hypertension – left ventricular hypertrophy regression and salt balance.

Contact Person
Professor H.F. Tse
Tel: 2255 4694
Fax: 2818 6304
Email: hftse@hku.hk

Clinical pharmacology – cardiovascular risk factors in the community, including hypertension and the metabolic syndrome. Peptides and cytokines regulating cardiovascular function and inflammation.

Pharmacogenetics, pharmacogenomics and precision medicine

Improving drug therapy – clinical trials, meta-analysis of clinical trials, developing clinical guidelines, assessing utilisation and cost-effectiveness, and drug safety.

Contact Person
Professor B.M.Y. Cheung
Tel: 2255 4347
Fax: 2818 6474
Email: mycheung@hku.hk

Endocrinology and metabolism:
Molecular genetics and pathogenesis of atherosclerosis, diabetes and diabetic complications; clinical and basic studies on obesity and adipocyte-derived hormones;  adipose tissue browning, immunometabolism; pathogenesis and management of autoimmune thyroid disease; genetics and environmental determinants of osteoporosis.

Contact Person
Professor K.S.L. Lam
Tel: 2255 3348
Fax: 2816 2863
Email: ksllam@hku.hk

Gastroenterology and hepatology:
Functional GI disorders – dyspepsia, gastro-esophageal reflux diseases, non-cardiac chest pain, constipation; gene delivery system and new drug development in treatment of stomach and colon cancer.

Helicobacter pylori – disease pathogenesis, molecular microbiology, carcinogenesis.

Stomach and colon cancer – signal transduction and apoptosis pathways, chemoprevention, clinical trials.

Hepatitis B and C viruses – molecular virology, associated mutations, natural progression and treatment.

Chronic liver diseases – serology and biomarkers, disease profile of alcoholic liver disease, non-alcoholic fatty liver disease, primary biliary cholangitis, autoimmune hepatitis, Wilson’s disease and drug-related liver injury

Contact Persons
Professor W.K. Leung (for Gastroenterology)
Tel: 2255 3348
Fax: 2816 2863
Email: waikleung@hku.hk

Professor M.F. Yuen (for Hepatology)
Tel: 2255 4477
Fax: 2816 2863
Email: mfyuen@hku.hk

Geriatrics:
Dementia – early detection of Alzheimer’s disease (AD), genetic studies in familial Alzheimer’s diseases and late onset AD, biochemical bio-markers in the diagnosis of AD, the roles of sex hormones and growth hormone in AD, use of neuropsychological tests and magnetic resonance imaging (MRI) in mild cognitive impairment and AD.

Contact Person
Professor L.W. Chu
Tel: 2255 3315
Fax: 2974 1171
Email: lwchu@hku.hk

Haematology:
Clinical protocols for treatment of leukaemia and lymphomas; detection of minimal residual disease and molecular mechanisms in haematologic malignancy; clinical protocols for bone marrow transplantation; infective and neoplastic complications of bone marrow transplantation; molecular genetics of haematological malignancies; basic research in pathogenesis of blood cancers; normal and leukaemic haematopoietic stem cell study using NOD/SCID mice; embryonic haematopoiesis and gene regulation studies in zebrafish.

Contact Person
Professor Y.L. Kwong
Tel: 2255 5859
Fax: 2974 1165
Email: ylkwong@hku.hk

Molecular medicine:
Development of novel diagnostic techniques (including non-invasive prenatal diagnosis and pre-implantation diagnosis) for common genetic diseases, such as thalassemias, haemophilias, Duchenne muscular dystrophy, spinal muscular atrophy and Huntington’s disease; genome-wide scan with microsatellite markers for linkage of new disease genes; development of DNA microarray technology to diagnose and elucidate the molecular pathology of genetic diseases and cancers.

Contact Person
Professor Y.L. Kwong
Tel: 2255 5859
Fax: 2974 1165
Email: ylkwong@hku.hk

Nephrology:
Immunological and molecular pathogenic mechanisms in glomerular and tubulointerstitial diseases, with special focus on lupus nephritis, diabetic nephropathy, inflammation and fibrosis. Translational studies on mesothelial cell biology, peritoneal inflammation and fibrosis, and clinical outcomes in peritoneal dialysis.

Contact Person
Professor D.T.M. Chan
Tel: 2255 4542
Fax: 2816 2863
Email: dtmchan@hku.hk

Neurology:
Parkinson’s disease – pathogenesis and treatment with focus on the role of mitochondrial dysfunction LRRK2 mutations, and autophagy in modifying progression of disease.

Amyotrophic lateral sclerosis: discovery of novel biomarkers and neuroimaging markers.

Contact Person
Professor S.L. Ho
Tel: 2255 3315
Fax: 2974 1171
Email: slho@hku.hk

Stroke and cerebrovascular disease: experimental neuroprotection studies using in vivo and in vitro stroke models; clinical stroke research on advanced neuroimaging, novel therapies and biomarkers.

Functional neuroimaging using functional MRI and high resolution EEG in healthy subjects and patients.

Contact Person
Professor R.T.F. Cheung
Tel: 2255 4049
Fax: 2818 6474
Email: rtcheung@hku.hk

Neuroimmunology and Neuroinflammation – clinical, neuroradiological, in vitro and in vivo studies relating to autoimmune and immune mediated neurological disorders including neuromyelitis optica, multiple sclerosis, autoimmune encephalitis, myasthenia gravis and paraneoplastic neurological disorders; as well as neuroinflammation in Alzheimer’s disease (AD) and development of novel therapies with anti-inflammatory and neuroprotective properties in AD by cell and animal models.

Intracerebral  haemorrhage with specific focus on hemorrhagic transformation of cerebral infarctions, intracerebral haemorrhage complicating therapy with anticoagulants and anti-platelet agents.

Contact Person
Dr K.H. Chan
Tel: 2255 3315
Fax: 2974 1171
Email: koonho@hku.hk

Stroke: epidemiology, blood pressure management, small vessel disease, cognitive impairment, neuroimaging, biomarkers, psychosocial aspects, health economics. 

Contact Person
Dr Gary K.K. Lau
Tel: 2255 3315
Fax: 2974 1171
Email: gkklau@hku.hk

Respiratory medicine:
Chronic obstructive pulmonary disease (COPD) and bronchiectasis – mechanisms of neutrophil recruitment; role of transforming growth factor-beta(1) (TGF-beta(1)); airways remodelling.

Lung cancer – molecular genetics; cytotoxic chemotherapy, immunotherapy and biologic therapy for advanced non-small cell carcinoma; circulating tumor markers; environmental risk factor and genes interaction in pathogenesis.

Obstructive sleep apnoea – cardiometabolic aspects of OSA;mechanisms of vascular homeostasis; interactions of OSA and obesity on cardiometabolic pathogenesis using intermittent hypoxia exposure animal and cell culture models.

Biomarkers of lung cancer, COPD and lung function, bronchial epithelial injury and stem cell regeneration.

Contact Person
Professor M.S.M. Ip
Tel: 2255 4605
Fax: 2816 2863
Email: msmip@hku.hk

Rheumatology:

Systemic lupus erythematosus
(1)  Immunopathogenesis including the role of dendritic cells and the cytokine / chemokine networks
(2)  Derivation of clinical disease assessment tools
(3)  Clinical and socio-economic outcomes

Rheumatoid arthritis
(1)  Clinical and socio-economic outcomes
(2)  Understanding the role of biologics in the treatment of rheumatoid arthritis

Spondyloarthritis - Derivation of clinical and radiological assessment tools 

Immunology - The function of C-type lectin receptors on immune cells

Contact Person
Professor C.S. Lau
Tel: 2255 3356
Fax: 2818 6474
Email: cslau@hku.hk

Departmental Postgraduate Admission Advisors
Professor Y.L. Kwong
Tel: 2255 5859
Fax: 2974 1165
Email: ylkwong@hku.hk

Professor M.S.M. Ip
Tel: 2255 4250
Fax: 2816 2863
Email: msmip@hku.hk

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