Department of Clinical Oncology

http://www.oncology.hku.hk/
How do cancer cells evade attacks from the immune system?
How does cancer stem cells contribute to the transformation of normal tissue to malignant forms?

Major Research Areas

Clinical research:
New radiotherapy techniques including the use of 3-dimensional computer planning systems; stereotactic radiotherapy and conformal radiotherapy; nasopharyngeal carcinoma, especially its relationship with the Epstein Barr virus; multimodality treatment that aims at improving control and minimising side effects; multimodality treatment of gonadal and extragonadal germ cell tumours, colorectal, esophageal cancer, breast cancer, and thyroid cancer, and elucidation of related prognostic factors.

Identification of cancer-related genes:
Elucidation of the tumourigenesis process in hepatocellular carcinoma (HCC), nasopharyngeal carcinoma (NPC), colorectal cancer, esophageal cancer, ovarian cancer, and lung cancer, through characterisation of isolated oncogenes or tumour suppressor genes with recently-developed techniques, such as comparative genomic hybridisation (CGH), tissue microarray, genomic DNA microarray, multi-colour fluorescence in situ hybridisation (mFISH), proteomics, chromosome microdissection, and cDNA subtraction.

Contact Persons
Professor Anne W.M. Lee
Tel: 2255 5050
Fax: 2872 6426
Email: awmlee@hku.hk

Professor D.L.W. Kwong
Tel: 2255 4521
Fax: 2872 6426
Email: dlwkwong@hku.hk

Professor X.Y. Guan
Tel: 3917 9782
Fax: 2816 9126
Email: xyguan@hku.hk

Discovery and validation of candidate genes in nasopharyngeal and esophageal cancers:
Understanding the molecular genetic basis of human cancers through molecular, cytogenetic, and functional approaches; approaches include chromosome and gene transfers, microarray hybridisation, Fluorescent In Situ Hybridization (FISH), microsatellite typing, in vitro cell assays, in vivo animal assays, tissue microarrays; characterisation of genes of interest in cell transformation, cell cycle, motility, invasion, metastasis, and angiogenesis; validation of clinical utility as biomarkers.

Research opportunities for basic, translational, and clinical studies focused on nasopharyngeal carcinoma (NPC) are available for our Area of Excellence programme. These areas include genomic studies on NPC and Epstein-Barr virus, discovery and use of biomarkers for NPC, translational studies on cancer stem cells/tumour microenvironment, discovery of novel molecularly targeted drugs for treatment, and improved molecular imaging and clinical care of NPC patients.

Contact Person
Professor M.L. Lung
Tel: 3917 9783
Fax: 2872 6426
Email: mlilung@hku.hk

Departmental Postgraduate Admission Advisors
Professor Anne W.M. Lee
Tel: 2255 5050
Fax: 2872 6426
Email: awmlee@hku.hk

Professor D.L.W. Kwong
Tel: 2255 4521
Fax: 2872 6426
Email: dlwkwong@hku.hk

Professor X.Y. Guan
Tel: 3917 9782
Fax: 2816 9126
Email: xyguan@hku.hk

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