Cindy LH Yang, PhD

Research Officer, Molecular Chinese Medicine Laboratory Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China

Dr. Yang graduated from the Hong Kong University of Science and Technology with PhD degree in Marine Environmental Science. She trained in analytical chemistry and marine natural product chemistry.

Current Research Interests:

1. Isolation and identification of bioactive natural compounds from medicinal herbs
2. Authentication and characterization of medicinal herbs

Representative publications:

1. Or CT, Yang CLH, Law AHY, Li JCB & Lau ASY. Isolation and identification of anti-inflammatory constituents on microglia from Ligusticum chuanxiong and their underlying mechanisms of action. Neuropharmacology, conditionally accepted, November 2010.
   
   
2. Yang CLH, Chik SCC, Li JCB, Cheung BKW & Lau ASY. Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of Black Cohosh and related Cimicifuga species on human primary blood macrophages. Journal of Medicinal Chemistry, 52(21):6707-15.
   
   
3. Lee DCW, Yang CLH, Chik SCC, Li JCB, Rong JH, Chan GCF & Lau ASY 2009. Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells. Journal of Translational Medicine, 7:34.
   
   
4. An JH, Lee DCW, Law AHY, Yang CLH, Poon LLM, Lau ASY & Jones SJM 2009. A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase. Journal of Medicinal Chemistry, 14:2667-72.

Biotechnology Patents issued/applied:

1. US Patent: Materials and methods for prevention and treatment of viral infections., Type: Provisional. PI: Allan SY Lau. Co-I: Anna HY Law and Cindy LH Yang. Assignees: HKU Versitech Limited and Purapharm International. Priority date for IP: 2010.
   
   
2. US Patent: novel therapeutic methods for treating inflammation and immune system disorders., Type: Provisional. PI: Allan SY Lau. Co-I: Terry CT Or, Cindy LH Yang and Anna HY Law. Assignees: HKU Versitech Limited and Purapharm International. Priority date for IP: 2009.
   
   
3. US Patent: Novel compound and uses thereof for treating inflammation and modulating immune responses., Type: Provisional. PI: Allan SY Lau. Co-I: Cindy LH Yang, James CB Li, and Stanley C Chik. Media: US Provisional patent Application Serial # 61/143-925. Assignees: HKU Versitech Limited and Purapharm International. Priority date for IP: 2009.

Conference papers:                     

1. Yang CLH, Chik SCC, Li JCB, Cheung BKW, Lau ASY. Anti-inflammatory mechanisms of Black Cohosh on human primary blood macrophages via its downregulation of signal transduction and transcription factor activation. The 8th Meeting of Consortium for Globalization of Chinese Medicine (CGCM), Nottingham, 27 August 2009, 2009.
2. Or CT, Yang CLH, Cheung BKW and Lau ASY. Mechanisms of Ligusticum chuanxiong (LCX) extracts in the suppression of proinflammatory cytokine expression in blood macrophages. The 9th World Congress on Inflammation, Tokyo, Japan, 8 July 2009, 2009.
   
3. An J, Law HY, Lee DCW, Yang CLH, Poon LLM, Jones SJM and Lau ASY Identification of a Novel small-molecule inhibitor of avian influenza H5N1 virus through computational screening against neuraminidase, 5th Congress of Asia Society for Pediatric Research, Hangzhou, Zhejiang, PR China, 21-24 May 2009, 2009.
   
4. Li CB, Yang LH, Chik CC, Cheung KW, Tam KH, Ko KM, Lau SY. The immunomodulatory effects of post-stroke rehabilitation formulation: a genome-wide study. The 7th Meeting of Consortium for Globalization of Chinese Medicine (CGCM), Taipei, 2008
   
5. Lee DCW, Chik SCC, Yang LH, Li CB, Rong J, Lau G, Tam PKH and Lau ASY. Application of Microarray and Gas Chromatography-Mass Spectrometry Technologies to Investigate the Immunomodulatory Effects of Ginseng on Human Monocytic Cells. The 6th Meeting of Consortium for Globalization of Chinese Medicine (CGCM), Beijing, 2007.
   

Grants funded:

HKU CRACG Grant #200807176139
URC/CRCG: (#200807170495)

Contact Information:

Dr. Cindy LH Yang
Email: cindyy@hku.hk
Phone: (852) 2589-0538