Programme(s) to which this project applies:
|☒ MPhil/PhD||☑ MRes[Med]||☒ URIS|
Area of Research
Reproduction, Development and Growth; Stem cell and regenerative medicine
Objective and Significance
To decipher the molecular controls regulating the differentiation of progenitor cells within a developing joint to identify the ‘true’ progenitor cells for the generation of anterior cruciate ligament and the articular cartilage. The knee ligaments in the knees can be tore during sport activities and do not repair. Like wise, the articular cartilage also do not repair well once damaged that will lead to a degenerative condition such as osteoarthritis. Thus, finding the most effective stem/progenitor cells for the repair of these ligament will provide novel therapeutic treatments.
Research Plan and Methodology
The general approach is to decipher the precise cellular differentiation in the formation of a knee joint in the mouse, using specific genetic tools that allow the tagged and trace cells in development. We will use molecular biology techniques to identify cells and to isolate cells for further investigation. A powerful approach is the use of single cell RNA sequencing to identify and characterise the difference cell population in a developing knee joint, and to use bioinformatics tools to cluster and map the potential ‘time line’ in the differentiation process, follow by validation of the hypothesis back in the developmental process and then translated the information for the differentiation of human cells and test their potential to repair a damaged adult mouse knee joint as a proof-of-principle experiment.
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