Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☑ URIS|
Neural crest (NC) is a transient population of multipotent progenitor cells in vertebrates, contributing to the formation of various organ systems. Aberrant NC development results in a myriad of birth defects and diseases, such as Hirschsprung (HSCR) disease and congenital septal defects which are attributed to the developmental defects of enteric and cardiac NC, respectively. We utilise an integrated approach with various mouse and pluripotent stem cells (hPSCs)-cell and -organoid based models, single-cell transcriptomic and epigenetic analyses, to identify the key regulators controlling cell-state transition and for a better understanding of the molecular control underlying various congenital diseases.
Followings are the key research areas:
Professor ESW Ngan, Department of Surgery
Prof Ngan has completed her PhD from the University of Hong Kong and received her postdoctoral training in Baylor College of Medicine, Houston, USA. Currently, she is the Professor of the University of Hong Kong. She has published her research findings in various prestigious journals including Gastroenterology, Science Advances, Genome Biology, Journal of Clinical Investigation, Journal of National Cancer Institute and PNAS. She has been serving as the member of the scientific and organization committees of various international conferences and the editorial board member of various reputed scientific journals.
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