Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
TSPYL proteins contain a highly conserved nucleosome assembly protein domain but their biological importance is largely unknown. Our group has been elucidating their functions both in vitro and in vivo. We have been using gene knockout and gene knockdown and the data suggest that TSPYL genes are important tumour suppressors. To address the mechanisms involved, we shall find out how TSPYL proteins regulate gene expression during development and tumour growth.
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