Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
In each ejaculation, millions of spermatozoa are deposited in the vagina but only 10-1000 spermatozoa can reach the fallopian tube for fertilisation. The huge reduction in spermatozoa getting to the fallopian tube is the result of an in vivo selection ensuring that only the fertilisation-competent spermatozoa can interact with the oocyte. To be selected, the spermatozoa must be capable of interacting with the female reproductive tract and penetrating the cumulus oophorus and the zona pellucida (ZP). Treatment of human subfertility with assisted reproduction technologies (ART) bypasses the natural selection processes for high quality sperm. Most of the current sperm selection techniques in ART show distinct limitations in that they do not necessarily select spermatozoa according to their functional competence and/or genetic quality. It can introduce a defective spermatozoon to the oocyte leading to undesirable outcome. We are interested in studying the functions and mechanism of natural sperm selection process in humans. Currently, the following projects will be offered:
Dr PCN Chiu, Department of Obstetrics and Gynaecology
Dr Philip CN Chiu received his PhD at the University of Hong Kong in 2004. He is currently an Associate Professor in the Department of Obstetrics and Gynaecology, the University of Hong Kong and the Principal Research Scientist at the Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong-Shenzhen Hospital, China. He also serves as the President of the Hong Kong Society of Endocrinology, Metabolism and Reproduction. Dr Chiu has more than 15 years of research experience in reproductive biology and has more than 70 international high-impact publications including Science, PNAS, Diabetes, Human Reproduction Update, Mucosal Immunology and Nature Communications. These articles has been extensively cited for over 2000 times (h-index=28). His current research interests focus on human fertilisation, immune cells-trophoblast interactions at the maternal-fetal interface and trophoblast function/differentiation.
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