Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Skeletal disorder is a heterogeneous group of conditions associated with various abnormalities of the skeleton (e.g., bone, cartilage, tendon, and ligament), most of which are the results of genetic defects that disrupt the normal skeletal growth and development. There are more than 400 different skeletal disorders, which can present any time from the prenatal period to adult life. They occur in 1/5,000 births, and some are lethal. This project aims to investigate the genetic bases of some skeletal disorders (e.g., congenital scoliosis, adolescent idiopathic scoliosis, osteogenesis imperfecta) and understand their underlying pathogenic mechanisms using transgenic animal models (e.g., zebrafish or mouse).
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