Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Virus research has come back to the limelight due to the emerging and re-emerging viruses, even devastating viruses, in the past decades. Conventionally, in vitro studies of virus-host interaction have hinged on the immortalised and cancer-derived cell lines that comprise homogenous clonal cells. Unfortunately, these cell lines can barely model native human epithelia, which are composed of multiple cell populations. Thus, a biologically relevant and readily available in vitro model system is desperately needed to understand virus-host interaction. The major contribution of our team to the field includes establishing organoids for modelling and studying virus-host interaction.
The PhD project will focus on developing organoids studying clinically important viruses, especially human enteric and respiratory viruses. These researches will reveal viral infection and virus-host interaction in an exciting and unprecedented perspective.
We are looking for candidates who are self-motivated and experienced in cellular biology and virology.
Dr J Zhou, Department of Microbiology
Dr Zhou has developed a research focus of establishing adult stem cell-derived organoids for studying virus-host interaction. We have established human lung and intestinal organoid culture platforms for investigating an array of human respiratory and enteric viruses.
For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description. Interested candidates are advised to enclose with your email:
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