Research Projects
Neuroprotection for Ischaemic and Haemorrhagic Stroke


Programme(s) to which this project applies:

☒ MPhil/PhD ☑ MRes[Med] ☒ URIS
About the Project

Objective and Significance:

Stroke is a devastating condition that is increasingly common in our aging population. Currently, there is no effective treatment for haemorrhagic stroke; surgical evacuation of intracerebal haematoma may save lives but functional outcomes remain poor. For ischaemic stroke, the use of adjunctive neuroprotective measures to complement existing methods of cerebral reperfusion is an exciting field of study. This project encourages and enables the student to investigate the use of novel neuroprotective therapy in animals with induced intracerebral haemorrhage (ICH) or cerebral ischaemia. Potential therapeutic strategies targeting inflammatory response mechanisms, cell death pathways and others may be carried out in the Supervisor‘s laboratory. The ultimate goal is to translate preclinical laboratory findings into readily applicable clinical treatment for stroke. Research Plan and Methodology: The student will be guided to formulate his or her own experimental hypothesis and study design. ICH or middle cerebral artery occlusion (MCAO) is induced in rodents (rats or mice). The experimental treatment will be given, followed by assessments of neurological outcome, imaging finding and pathological changes of post-mortem brain specimens. The student will thereby acquire skills and knowledge in performing general anaesthesia, brain surgery and functional assessment in small animals, and to conduct basic laboratory techniques such as the harvesting and processing of brain specimens, western blotting, PCR, and other molecular biology assays.

About the Supervisor

Professor GKK Leung, Department of Surgery

Biography
gkkleung@hku.hk

Next Step?

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.