Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☑ URIS|
Brain-derived neurotrophic factor (BDNF) is the well-studied member of neurotrophin family that plays fundamental roles in many distinct processes in the nervous system, including neuronal outgrowth, survival, and differentiation, as well as synaptic formation, plasticity, and elimination. An important question of how BDNF could serve diverse functions, even in the same cell, remains unclear. BDNF appears to exert synapse-selective actions, implicating potential activity-dependent mechanisms of localized BDNF release in this process. In this project, advanced live-cell imaging will be performed to address how the spatiotemporal release of BDNF proteins is regulated at the sites of AChR clusters at developing NMJs.
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