Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Chronic kidney disease (CKD) is an escalating public health problem associated with considerable morbidity, mortality and treatment cost. Common causes of CKD include diabetes and hypertension. There is currently no effective treatment for CKD.
CKD is characterized by the progressive accumulation of matrix proteins in the kidney parenchyma, which replaces normal kidney tissue with fibrous matter leading to a loss of kidney function. Increased fibrogenesis occurs when a wound-healing response fails to resolve after inflammatory injury. Irrespective of the primary aetiology, tubulo-interstitial fibrosis is considered the final common pathway that drives CKD to end-stage renal failure. The underlying mechanisms that contribute to tubulo-interstitial fibrosis remains undefined.
Our studies aim to investigate the molecular and immunological mechanisms that mediates CKD using animal studies and in vitro studies, with particular focus on cellular mechanisms and phenotypic manifestations in resident renal tubulo-interstitial cells.
A greater understanding of disease pathogenesis and the identification of key pathways and molecules that contribute to the initiation of CKD may allow for the development of novel therapeutic agents.
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