Research Projects
Molecular and Cellular Immuno-Dysregulation in Systemic Lupus Erythematosus

Programme(s) to which this project applies:

☑ MPhil/PhD ☒ MRes[Med] ☒ URIS
About the Project

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder that predominantly affect young females. Immunologically, SLE is characterized by a loss of tolerance to self-antigens, T and B cell activation, and elevated pathogenic autoantibody production. The aetiology of SLE is highly complex with interplay of genetic, hormonal and environmental factors. This also entails heterogeneity in clinical manifestations. Our team has previously identified phenotypic, functional abnormalities as well as the underlying mechanisms in various immune cellular compartments in SLE patients. Through understanding the underlying causes of cellular and molecular immunodysregulation in SLE, we aim to identify potential therapeutic targets for exploitation in clinical settings. Our current research projects focus on the following areas:

  1. Elucidation of the roles of regulatory non-coding RNAs in SLE
  2. Dissecting SLE disease heterogeneity by Omics technologies
About the Supervisor

Dr VSF Chan, Department of Medicine

HKU Scholars Hub

Next Step?

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website.

General admission enquiries should be directed to