Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☑ URIS|
Microbiota-gut-brain axis has been an emerging field and revolutionized study in pathology, diagnosis and treatment of neurological disorders. Crosstalk between gut microbiota and brain can be accomplished via immune system. In this study, lipopolysaccharide (LPS) will be used to induce systemic inflammation and neuroinflammation. Our hypothesis is that gut microbiota is an important mediator between the immune system and the central nervous system; and dietary intervention by selected prebiotics helps alleviating both systemic and neural inflammatory responses. This study investigates the link between gut microbiota, systemic and neural inflammation and identifying the metabolites involved in manipulating the immune network.
Dr RCC Chang, School of Biomedical Sciences
Dr Chang’s research interest is on four directions.
He has published over 170 peer-reviewed papers, 15 book chapters and edited 5 books in these areas. His h-index is 47 by Scopus. He is also listed as top 1% scholar since 2018.
Selected Publications (* = corresponding author)
Research in this laboratory is supported by GRF, HMRF, ITC, RGC-NSFC, BrightFocus Foundation.
Dr Chang is the Chief Editor for American Journal of Alzheimer’s Disease and Other Dementias, Senior Editor/Asia Chief Editor for Journal of Neuroimmune Pharmacology, Associate handling Editor for Frontiers in Neurology, Frontiers in Neurosciences and Frontiers in Psychiatry. He is in the Scientific Advisory Board of International AD/PD Symposium, and Scientific Review Committee in Alzheimer Association. He is the member of editorial board of more than 20 different journals, and grant reviewer for different grant agencies/Foundations for different countries. He is the reviewer and speaker to make decision for the final round of grant proposal for Alzheimer Association, USA. Apart from Scientific community, Dr Chang has obtain Knowledge Exchange Fund to promote neuroscience and biotechnology education in high school.
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