Research Projects
Investigating the Modulating Effects of Microbiota in Neuroinflammation/Neurodegeneration


Programme(s) to which this project applies:

☑ MPhil/PhD ☒ MRes[Med] ☑ URIS
About the Project

Microbiota-gut-brain axis has been an emerging field and revolutionized study in pathology, diagnosis and treatment of neurological disorders. Crosstalk between gut microbiota and brain can be accomplished via immune system. In this study, lipopolysaccharide (LPS) will be used to induce systemic inflammation and neuroinflammation. Our hypothesis is that gut microbiota is an important mediator between the immune system and the central nervous system; and dietary intervention by selected prebiotics helps alleviating both systemic and neural inflammatory responses. This study investigates the link between gut microbiota, systemic and neural inflammation and identifying the metabolites involved in manipulating the immune network.

About the Supervisor

Dr RCC Chang, School of Biomedical Sciences

Dr Chang’s research interest is on four directions.

  1. Pathophysiological changes of Alzheimer’s disease (AD),
  2. How different risk factors (post-operative cognitive dysfunctions, periodontitis, depression, cigarette smoking, air pollutants) stimulate systemic inflammation to affect neuroimmune responses leading to AD,
  3. Spreading of neurodegeneration in Parkinson’s disease dementia, and
  4. Neurodegeneration of the retina and deterioration of visual functions in Alzheimer’s disease.

He has published over 170 peer-reviewed papers, 15 book chapters and edited 5 books in these areas. His h-index is 47 by Scopus. He is also listed as top 1% scholar since 2018.

 

Selected Publications (* = corresponding author)

  1. Lee K, Lai HM, Sørensen MH, Hui ESK, Ma VWS, Cho WCS, Ho YS, Chang RCC* (2021) Optimized tissue clearing minimizes distortion and destruction during tissue delipidation. Neuropathol. Applied Neurobiol., 47, 441-453 (doi: 10.1111/nan.12673). [Corresponding author; Impact factor: 8.09; Rank of Journal: 4/90 (Top: 4.44%) in the field of Pathology]
  2. Chen XK, Kwan JSK, Chang RCC*, Ma ACH (2021) 1-Phenyl 2-thiourea (PTU) activates autophagy in zebrafish embryos. Autophagy, 17, 1222-1231 (doi: 10.1080/15548627.2020.1755119). [Co-correspondence author; Impact factor: 16.016; Rank of Journal: 14/201 (Top 6.97%) in the field of Cell Biology]
  3. Liu Y, Chu JMT, Yan T, Zhang Y, Chen Y, Chang RCC*, Wong GTC (2020) Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice. J Neuroinflamm., 17, 4 (doi: 10.1186/s12974-019-1653-7). [Co-correspondence author; Impact factor: 8.322; Rank of Journal: 23/293 (Top 7.9%) in the field of Neuroscience]
  4. You R, Ho YS, Hung CHL, Liu Y, Huang CX, Chan HN, Ho SL, Lui SY, Li HW, Chang RCC* (2018) Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activation. Particle Fibre Toxicol., 15: 28 (doi: 10.1186/s12989-018-0263-3). [Correspondence author; Impact factor: 9.4; Rank of Journal: 3/99 (Top 3.03%) in the field of Toxicology]
  5. Hung CHL, Cheng SSY, Cheung YT, Wuwongse S, Zhang NQ, Ho YS, Lee SMY, Chang RCC* (2018) A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration. Redox Biol., 14, 7-19 (doi: 10.1016/j.redox.2017.08.010). [Corresponding author; Impact factor: 11.799; Rank of Journal: 21/313 (Top 6.7%) in the field of Biochemistry & Molecular Biology]
  6. Huang CX, Irwin MG, Wong GTC, Chang RCC* (2018) Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model. J. Neuroinflamm, 15, 147 (doi: 10.1186/s12974-018-1163-z). [Correspondence author; Impact factor: 8.322; Rank of Journal: 23/293 (Top 7.85%) in the field of Neuroscience

 

Research Grants

Research in this laboratory is supported by GRF, HMRF, ITC, RGC-NSFC, BrightFocus Foundation. 

 

Community Services

Dr Chang is the Chief Editor for American Journal of Alzheimer’s Disease and Other Dementias, Senior Editor/Asia Chief Editor for Journal of Neuroimmune Pharmacology, Associate handling Editor for Frontiers in Neurology, Frontiers in Neurosciences and Frontiers in Psychiatry. He is in the Scientific Advisory Board of International AD/PD Symposium, and Scientific Review Committee in Alzheimer Association. He is the member of editorial board of more than 20 different journals, and grant reviewer for different grant agencies/Foundations for different countries. He is the reviewer and speaker to make decision for the final round of grant proposal for Alzheimer Association, USA. Apart from Scientific community, Dr Chang has obtain Knowledge Exchange Fund to promote neuroscience and biotechnology education in high school.

 

Biography
HKU Scholars Hub
Laboratory Facebook
ResearchGate
rccchang@hku.hk

Next Step?

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website.

General admission enquiries should be directed to rpgmed@hku.hk.