Programme(s) to which this project applies:
|☒ MPhil/PhD||☑ MRes[Med]||☒ URIS|
Objective and Significance:
To study the regulatory components mediating the dysregulated inflammasome responses in systemic lupus erythematosus (SLE)
Significance: SLE is a prototypic autoimmune disease with multiple etiological pathogenic attributes. Dysregulated inflammasome responses have been observed in SLE patients but the underlying pathological mechanism is not well understood. Understanding the regulatory components mediating inflammasome dysregulation may reveal molecular targets for potential therapeutic intervention.
Research Plan and Methodology:
Serological factors in SLE patients are known to modulate functions of peripheral leukocytes. By exposing normal leukocytes with different serological components from SLE patients, it is anticipated to modulate the inflammasome responses, recapitulating the functional perturbations observed in SLE patients.
Outline of research methods:
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HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.
HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.