Programme(s) to which this project applies:
|☒ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Nasopharyngeal carcinoma is a multifactorial epithelial malignancy associated with Epstein-Barr virus (EBV) infection, host genetics, and environmental factors. According to statistics from Hong Kong Cancer Registry, in males, NPC is the 6th most common cancer with incidence rates of 18.2 per 100,000, and is the 9th leading cause of cancer death in 2017. As it often occurs in middle-aged males, this deadly disease has become a severe health issue and has heavy financial burdens for medical care in Hong Kong. It is reported that 15%-58% of cases do not respond well to conventional treatments, resulting in poor clinical outcomes. Therefore, new treatment strategy is urgently needed for these patients.
Recently, cancer immunotherapy has attracted much attention as a treatment strategy for advanced NPC. In addition to immune checkpoint inhibitors, neoantigen-based personalized vaccines have also shown promising results for cancers treatment. Neoantigens were originally defined as a class of antigens that are derived from tumour-specific mutations. Neoantigen immunotherapy stimulates the patient’s own immune system against these neoantigens to recognize and eliminate the cancer cells.
In this project, we expect to blueprint neoantigens derived from somatic mutations in NPC by an integrative WES data analysis. The utility of somatic mutations as putative tumour neoantigens will be evaluated in terms of peptide expression and binding affinity with MHC molecules. We will evaluate the feasibility of performing the immunopeptidomic study in NPC and identify the potential effective neoantigens. Identification of effective neoantigens will help us understand the mechanisms underlying tumour development. The study will also provide a new treatment strategy for NPC by identifying more effective neoantigens as therapeutic targets. Designing anti-cancer vaccines based on these neoantigens can be an effective immunotherapy, especially for those who do not respond well to the conventional treatments. Therefore, the findings from this study will be valuable for both basic research and clinical applications.
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