Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
The human genome encodes multiple α- and β-tubulin gene families (i.e., isotypes) that have the protein expression profile varying with cell types and developmental stages. While single point mutations in a specific tubulin isotype have been associated with human diseases, the molecular mechanism by which tubulin isotypes confer microtubules’ functions remains poorly understood. Using our field-leading strategy to generate isotypically pure recombinant human tubulin, Ti Lab will employ combinatorial approaches of biochemistry, biophysics, chemical biology, and structural biology to investigate the intrinsic properties of different human tubulin isotypes. Please see the following references to learn more about Dr Ti’s previous work.
Dr JSC Ti, School of Biomedical Sciences
Dr Jeff Shih-chieh Ti joined the School of Biomedical Sciences as Assistant Professor in September 2019. Before joining HKU, Dr Ti received his Ph.D. (Biochemistry and Biophysics) from Yale University and then worked as a postdoctoral fellow at the Rockefeller University. His current research focuses on dissecting the mechanism by which cells organize microtubules into complex arrays that play critical roles in cell division, organelle transportation, and cell migration. In particular, employing protein biochemistry, proteomics, optical tweezers, single-molecule fluorescence microscopy, and cryo-electron microscopy, Dr Ti’s group will examine the molecular basis that confers the unique and essential functions of the diverse human tubulin isotypes.
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