Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
The placenta is an important organ not only for exchange of nutrients and waste between the fetus and the mother, but also for production of hormones and growth factors to support fetal growth. Key events in placentation include attachment of the blastocyst to the uterus, development of placenta villous, invasion of trophoblasts, placental angiogenesis and remodelling of spiral arteries in the decidua. Dysregulation of these processes is associated with various pregnancy complications leading to significant maternal and fetal death. Preeclampsia is one of these complications characterised by insufficient invasion of the trophoblast and maternal spiral artery remodelling. It affects 2-5% of all pregnancies, and is the leading cause of prenatal mortality and morbidity. Currently, there remains no therapeutic approach available for either treatment or prevention of preeclampsia. There is also no reliable diagnostic test for early prediction of preeclampsia before clinical symptoms developed. We are interested in how different intrinsic and extrinsic factors regulate human placental development and their associations with adverse pregnancy outcomes. Currently, the following projects will be offered:
Dr PCN Chiu, Department of Obstetrics and Gynaecology
Dr Philip CN Chiu received his PhD at the University of Hong Kong in 2004. He is currently an Associate Professor in the Department of Obstetrics and Gynaecology, the University of Hong Kong and the Principal Research Scientist at the Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong-Shenzhen Hospital, China. He also serves as the President of the Hong Kong Society of Endocrinology, Metabolism and Reproduction. Dr Chiu has more than 15 years of research experience in reproductive biology and has more than 70 international high-impact publications including Science, PNAS, Diabetes, Human Reproduction Update, Mucosal Immunology and Nature Communications. These articles has been extensively cited for over 2000 times (h-index=28). His current research interests focus on human fertilisation, immune cells-trophoblast interactions at the maternal-fetal interface and trophoblast function/differentiation.
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