Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Wnt/planar cell polarity (Wnt/PCP) signalling is a critical mechanism that conveys directional information to orchestrate polarized cell behaviours in a broad range of morphogenic and physiological processes. Disruption or aberrant activation of Wnt/PCP signalling underlies a variety of developmental defects and cancer malignancy. However, in contrast to the well-understood canonical branch of Wnt signalling (Wnt/ß-catenin signalling), the signalling mechanism of Wnt/PCP pathway remains largely elusive, which severely hampers our capacity to manipulate it therapeutically. We use molecular, biochemical, cellular and genetic approaches to investigate signalling mechanisms of Wnt/PCP pathway and their functions in normal developmental processes and human diseases.
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