Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Cancer invadopodia exhibit the unique protrusive F-actin network, degrade the extracellular matrix in proximity, and facilitate the invasive cell migration. It is postulated that this process is the mechanism used by carcinoma cells to gain access to the vasculature within connective tissue for dissemination throughout the body. Thus, any molecular target that inhibits invadopodium functionality will be a likely target for therapeutic exploitation. Several novel factors that can regulate the initiation and stabilisation of F-actin cytoskeleton have been identified. We aim to use the approach of molecular cell biology and quantitative fluorescence microscopy to uncover the underlying mechanism and to inhibit the assembly of invadopodia.
For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description. Interested candidates are advised to enclose with your email:
Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website.
General admission enquiries should be directed to firstname.lastname@example.org.