Research Projects
Cytoskeletal Regulations to Suppress Cancer Invadopodia


Programme(s) to which this project applies:

☑ MPhil/PhD ☒ MRes[Med] ☒ URIS
About the Project

Cancer invadopodia exhibit the unique protrusive F-actin network, degrade the extracellular matrix in proximity, and facilitate the invasive cell migration. It is postulated that this process is the mechanism used by carcinoma cells to gain access to the vasculature within connective tissue for dissemination throughout the body. Thus, any molecular target that inhibits invadopodium functionality will be a likely target for therapeutic exploitation. Several novel factors that can regulate the initiation and stabilisation of F-actin cytoskeleton have been identified. We aim to use the approach of molecular cell biology and quantitative fluorescence microscopy to uncover the underlying mechanism and to inhibit the assembly of invadopodia.

About the Supervisor

Dr CH Yu, School of Biomedical Sciences

My research team aims to decipher the molecular reorganisation and signal transduction at the cell-matrix adhesion. We provide four-year scholarship and are looking for one to two talented PhD students.

Biography
Laboratory Homepage
chyu1@hku.hk

Next Step?

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website.

General admission enquiries should be directed to rpgmed@hku.hk.