Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Nasopharyngeal carcinoma (NPC), highly associated with Epstein-Barr virus (EBV), is endemic in Hong Kong. Patients with NPC are all uniformly treated with high-dose radiation therapy, with additional (concurrent chemoradiation) or adjunct chemotherapy for advanced diseases. Unfortunately, about 30% of patients still relapse within 5 years despite such radical intensive treatment. There are many studies on new drugs targeting against various molecular targets of NPC. Unfortunately, none of these drugs have proven themselves efficacious for NPC.
The complex interplay and increasing diversity among cells that co-evolve with the tumour microenvironment (TME), suggesting that the ecosystem acquires a niche for cancer cells to modulate the immune landscape towards suppression. Therefore, understand the immunological changes in the NPC TME would be an important step for clinical translational studies.
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