Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
The stability and turnover of integrin-mediated adhesion play an important role in tissue organisation, immune surveillance, and cancer invasive migration(metastasis). Integrins are adhesion receptors on the plasma membrane that act as the physical linkage between cells and extracellular matrices. Factors that regulate the molecular compositions of cell-matrix adhesion have the direct impact on the adhesion formation, conversion, and disassembly. In this research project, we aim to investigate the functional role of novel matrix cleavage and redistribution of microtubule organisation centre in adhesion stability and cell migration.
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