Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
The application of single-cell RNA sequencing (scRNA-seq) to delineate tissue heterogeneity and complexity has become increasingly popular. Given its tremendous resolution and high-dimensional capacity for in-depth investigation, scRNA-seq offers an unprecedented research power. It is particularly useful in cancer research, where tumour tissue has a highly admixed cell population and hence is difficult to study. Although some software packages are available for scRNA-seq data analysis and visualization, it is still a big challenge for their usage, as they require significant level of bioinformatics skills. Hence, there is an urgent need for comprehensive software packages with graphical user interface to facilitate scRNA-seq studies.
Dr DWH Ho, Department of Pathology
My research focuses are bioinformatics analysis on high-throughput omics data and computational analysis tools development. I have particular interests on genomics studies of hepatocellular carcinoma (HCC) through the application of next generation sequencing, large-scale screening, liquid biopsy and single-cell genomics. I am also involved in multidisciplinary and integrative studies to investigate and understand the molecular mechanism of hepatocarcinogenesis and metastasis of HCC.
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