Research Projects
Integrated Chemical Biology Approach to Study Redox Signalling and Its Associations with Cancer


Programme(s) to which this project applies:

☑ MPhil/PhD ☒ MRes[Med] ☒ URIS
About the Project

Redox stress has been known to associate closely with cancer development and propagation. Yet, the underlying molecular mechanism remains largely unknown, partly because of difficulties in studying unstable and transient redox signaling. 

Our lab develops novel chemical probes and chemoproteomic technology to identify protein target(s) associated with redox signalling. Through trapping “reversible redox modification” into “permanent covalent tag”, we can identify these proteins by mass spectrometry (MS). We can also real-time visualize redox signalling events by fluorescence imaging. With that, we can better understand how redox stress contributes to cancer, and discover new redox-associated proteins which can be good targets for effective cancer therapy.

About the Supervisor

Dr CYS Chung, School of Biomedical Sciences

Dr Clive Chung is an Assistant Professor in the School of Biomedical Sciences and Department of Pathology, HKU. His research interest is in chemical biology, particularly in developing novel chemical compounds and technology to study underexplored but important redox signalling. His lab is also working on new covalent drug lead compounds for cancer therapy through specific targeting cancer-associated proteins.

Biography
cyschung@hku.hk

Next Step?

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website.

General admission enquiries should be directed to rpgmed@hku.hk.