Research Projects
Elucidate leukaemogenesis and development of novel therapy of acute lymphoblastic leukaemia


Programme(s) to which this project applies:
☑ MPhil/PhD ☒ MRes[Med] ☒ URIS

Acute lymphoblastic leukaemia has inferior prognosis in adult patients and relapse/refractory disease has dismal outcomes. This project will elucidate the leukaemogensis of acute lymphoblastic leukaemia by various techniques including bulk and single cell multiomic analysis, animal models. Also, we will develop novel therapy based on the findings. The results will enhance our understanding of molecular pathogenesis of acute lymphoblastic leukaemia and develop various more effective treatment to this disease.

Professor CF Sin, Department of Pathology

Professor Albert Sin Chun-fung joined the Department of Pathology of HKU since 2017. He is a specialist haematopathologist focusing on basic and translational research about leukaemia.

His current major theme of research is acute lymphoblastic leukaemia, with the focus in studying leukaemogenesis and development of novel therapies. Our team had reported the novel mechanism of bortezomib in treating acute lymphoblastic leukaemia. We are actively working on studying leukaemogenesis by various animal model system and techniques, including multiomics analysis. Moreover, our group is actively working on the study to evaluate the therapeutic efficacy and molecular mechanism of homoharringtonine in treating acute lymphoblastic leukaemia. 

HKU Scholars Hub
scf185@hku.hk

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information. 

Research @ Department of Pathology