HKUMed on COVID-19

26 May 2021

Respirology: Pathophysiology of infection with SARS-CoV-2—What is known and what remains a mystery

20 May 2021

Expert Review of Molecular Diagnostics: Comparative evaluation of a dual-target real-time RT-PCR assay for COVID-19 diagnosis and assessment of performance in pooled saliva and nasopharyngeal swab samples

Vox Sanguinis: International Forum on the Collection and Use of COVID-19 Convalescent Plasma: Responses

18 May 2021

Emerging Microbes & Infections: Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients

Vaccine: Prevalence and determinants of SARS-CoV-2 vaccine hesitancy in Hong Kong: A population-based survey

15 May 2021

International Journal of Radiation Oncology, Biology, Physics: Differential impact of COVID-19 on cancer diagnostic services based on body regions - A public facility-based study in Hong Kong

14 May 2021

The Lancet: Disease surveillance for the COVID-19 era: time for bold changes

13 May 2021

Nature Communications: Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein
Link to Press Release

Epidemiology: Theoretical framework for retrospective studies of the effectiveness of SARS-CoV-2 vaccines

Cell: TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation

11 May 2021

BMJ Open: International survey for assessing COVID-19’s impact on fear and health: study protocol

Journal of Colloid and Interface Science: Superhydrophobicity preventing surface contamination as a novel strategy against COVID-19!

09 May 2021

Emerging Microbes & Infections: A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters

Cell Reports: Dynamics of B cell repertoires and emergence of cross-reactive responses in patients with different severities of COVID-19

06 May 2021

Clinical Infectious Diseases: Role of epithelial-endothelial cell interaction in the pathogenesis of SARS-CoV-2 infection
Link to Press Release

The Lancet Healthy Longevity: COVID-19 vaccines in older adults with cancer: a Young International Society of Geriatric Oncology perspective

Journal of General Virology: Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells

BMJ Global Health: Ethical and policy considerations for COVID-19 vaccination modalities: delayed second dose, fractional dose, mixed vaccines

05 May 2021

Journal of Travel Medicine: Gut microbiome and resistome changes during the first wave of the COVID-19 pandemic in comparison with pre-pandemic travel-related changes

03 May 2021

JAMA Network Open: Clinical Characteristics and Transmission of COVID-19 in Children and Youths During 3 Waves of Outbreaks in Hong Kong
Link to Press Release

Theranostics: A SCID mouse-human lung xenograft model of SARS-CoV-2 infection

29 April 2021

International Journal of Environmental Research and Public Health: Impacts on Children and Adolescents’ Lifestyle, Social Support and Their Association with Negative Impacts of the COVID-19 Pandemic

28 April 2021

Frontiers in Pharmacology: Edible and Herbal Plants for the Prevention and Management of COVID-19

27 April 2021

Clinical Infectious Diseases: Substantial decline in invasive pneumococcal disease (IPD) during COVID-19 pandemic in Hong Kong

Clinical Chemistry and Laboratory Medicine: IFCC interim guidelines on rapid point-of-care antigen testing for SARS-CoV-2 detection in asymptomatic and symptomatic individuals

25 April 2021

Pharmaceuticals: COVID-19 Vaccines: A Review of the Safety and Efficacy of Current Clinical Trials

22 April 2021

Journal of Infection: COVID-19 transmission in Hong Kong despite universal masking

16 April 2021

Zoonoses and Public Health: Coronavirus seroprevalence among villagers exposed to bats in Thailand

History and Philosophy of the Life Sciences: Historical reflection on Taijin-kyōfushō during COVID-19: a global phenomenon of social anxiety?

15 April 2021

ACS Central Science: Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir
Link to Press Release

Building and Environment: Lack of cross-transmission of SARS-CoV-2 between passenger's cabins on the Diamond Princess cruise ship

The Journal of Infectious Diseases: Decreased use of broad-spectrum antibiotics during COVID-19 epidemic in South Korea

Signal Transduction and Targeted Therapy: Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery

Asia-Pacific Journal of Clinical Oncology: Prostate cancer management in the era of COVID-19: Recommendations from the Hong Kong Urological Association and Hong Kong Society of Uro-oncology

Microbiology Resource Announcements: Genome Sequences of Three SARS-CoV-2 ORF7a Deletion Variants Obtained from Patients in Hong Kong

14 April 2021

Clinical Infectious Diseases: Nosocomial outbreak of COVID-19 by possible airborne transmission leading to a superspreading event

13 April 2021

Nutrients: Impact of COVID-19 Pandemic on Serum Vitamin D Level among Infants and Toddlers: An Interrupted Time Series Analysis and before-and-after Comparison

12 April 2021

The Lancet Infectious Diseases: Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis

Hong Kong Medical Journal: Can COVID-19 vaccines stop the pandemic?

Hong Kong Medical JournalLooking beyond COVID-19 as a pandemic

10 April 2021

International Journal of Biological Sciences: In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor

International Journal of Biological Sciences: SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3

08 April 2021

Hong Kong Medical Journal: Returning to standard surgical practice during the COVID-19 pandemic

BMC Infectious Diseases: Clinical and CT features of mild-to-moderate COVID-19 cases after two sequential negative nucleic acid testing results: a retrospective analysis

NPJ Digital Medicine: Development of a multivariable prediction model for severe COVID-19 disease: a population-based study from Hong Kong

04 April 2021

Clinical Endocrinology: Role of Non‐Thyroidal Illness Syndrome in Predicting Adverse Outcomes in COVID‐19 Patients Predominantly of Mild to Moderate Severity

02 April 2021

Viruses: Evaluation of an Automated High-Throughput Liquid-Based RNA Extraction Platform on Pooled Nasopharyngeal or Saliva Specimens for SARS-CoV-2 RT-PCR

01 April 2021

Hong Kong Medical Journal: Findings from the first public COVID-19 temporary test centre in Hong Kong

31 March 2021

Signal Transduction and Targeted Therapy: Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

Medical Science Educator: Medical Education and Mental Wellbeing During COVID-19: a Student’s Perspective

Survey of Ophthalmology: A Review on the use of Telemedicine in Glaucoma and Possible Roles in COVID-19 Outbreak

29 March 2021

JMIR Public Health and Surveillance: Analyzing Cross-country Pandemic Connectedness During COVID-19 Using a Spatial-Temporal Database: Network Analysis

27 March 2021

Journal of Migration and Health: “We also deserve help during the pandemic”: The effect of the COVID-19 pandemic on foreign domestic workers in Hong Kong

Clinical Infectious Diseases: Assessing asymptomatic, pre-symptomatic and symptomatic transmission risk of SARS-CoV-2

25 March 2021

American Journal of Nephrology: Mass Screening Is Associated with Low Rates of Acute Kidney Injury among COVID-19 Patients in Hong Kong

24 March 2021

BMC Medicine: Evaluation of glycemic traits in susceptibility to COVID-19 risk: a Mendelian randomization study

23 March 2021

The Lancet Regional Health - Western Pacific: Phylogenomic analysis of COVID-19 summer and winter outbreaks in Hong Kong: An observational study!

Translational Behavioral Medicine: Fear of COVID-19 and its associations with perceived personal and family benefits and harms in Hong Kong

22 March 2021

Nature Reviews Microbiology: Transmissibility and transmission of respiratory viruses

Emerging Microbes & Infections: Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic

20 March 2021

International Journal of Environmental Research and Public Health: COVID-19 and Health-Related Quality of Life: A Community-Based Online Survey in Hong Kong

19 March 2021

Infection Control & Hospital Epidemiology: Multi-pronged infection control strategy to achieve zero nosocomial COVID-19 infection among Hong Kong healthcare workers in the first 300 days of combat

18 March 2021

The Lancet Infectious Diseases: The potential health and economic value of SARS-CoV-2 vaccination alongside physical distancing in the UK: a transmission model-based future scenario analysis and economic evaluation

17 March 2021

Translational Psychiatry: Psychiatric symptoms and behavioral adjustment during the COVID-19 pandemic: evidence from two population-representative cohorts

16 March 2021

Nature: Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

15 March 2021

Nature Medicine: Nowcasting epidemics of novel pathogens: lessons from COVID-19

BMJ Global Health: Evidence of the effectiveness of travel-related measures during the early phase of the COVID-19 pandemic: a rapid systematic review

Expert Opinion on Investigational Drugs: The Time to Offer Treatments for COVID-19

13 March 2021

Radiology: Cardiothoracic Imaging: Imaging Profile of the COVID-19 Infection: Radiologic Findings and Literature Review

Building and Environment: Probable airborne transmission of SARS-CoV-2 in a poorly ventilated restaurant

11 March 2021

Travel Medicine and Infectious Disease: Are travel restrictions helpful to control the global COVID-19 outbreak?

Global Public Health: More than a public health crisis: A feminist political economic analysis of COVID-19

BMJ: How the lessons of previous epidemics helped successful countries fight covid-19

Systematic Reviews: A systematic review and meta-analysis protocol examining the clinical characteristics and epidemiological features of olfactory dysfunction (OD) in coronavirus disease 2019 (COVID-19)

09 March 2021

Nature Communications: Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2

08 March 2021

Nature Communications: Real-time tracking and prediction of COVID-19 infection using digital proxies of population mobility and mixing

07 March 2021

Journal of Hospital Infection: Infection control challenges in handling recurrent blockage of sewage pipes in isolation facility designated for COVID-19 patients

06 March 2021

Ophthalmology and Therapy: Ophthalmological Considerations for COVID-19 Vaccination in Patients with Inflammatory Eye Diseases and Autoimmune Disorders

The Lancet: Single-dose Oxford–AstraZeneca COVID-19 vaccine followed by a 12-week booster

World Journal of Clinical Cases: Review of the risk factors for SARS-CoV-2 transmission

05 March 2021

Orphanet Journal of Rare Diseases: A thematic study: impact of COVID-19 pandemic on rare disease organisations and patients across ten jurisdictions in the Asia Pacific region

04 March 2021

The Lancet: Single-dose Oxford–AstraZeneca COVID-19 vaccine followed by a 12-week booster

Scientific Reports: On topological properties of COVID-19: predicting and assessing pandemic risk with network statistics

03 March 2021

BMC Medical Education: A comparative study regarding distance learning and the conventional face-to-face approach conducted problem-based learning tutorial during the COVID-19 pandemic

02 March 2021

Cell: Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system

Clinical Infectious Diseases: Emergence of a Severe Acute Respiratory Syndrome Coronavirus 2 virus variant with novel genomic architecture in Hong Kong

01 March 2021

Journal of Obstetrics and Gynaecology Research: COVID‐19 and gynecological cancers: Asia and Oceania Federation of Obstetrics and Gynecology oncology committee opinion

26 February 2021

Annals of the American Thoracic Society: Territory-wide Study on Hospital Admissions for Asthma exacerbation in COVID-19 Pandemic

25 February 2021

Cell Host & Microbe: Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies

24 February 2021

Cell Host & Microbe: Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies

22 February 2021

Nature Computational Science: Quantifying the uncertainty of CovidSim

18 February 2021

Endoscopy International Open: Impact of first wave of COVID-19 on outcomes of hospitalization for upper gastrointestinal bleeding in Hong Kong: a population-based study

17 February 2021

Immuno: Potential Beneficial Effects of Vitamin K in SARS-CoV-2 Induced Vascular Disease?

16 February 2021

BMJ: Co-producing the covid-19 response in Germany, Hong Kong, Lebanon, and Pakistan

Stroke: Qualitative Study of Chinese Stroke Caregivers’ Caregiving Experience During the COVID-19 Pandemic

Social Psychiatry and Psychiatric Epidemiology: Civil unrest, COVID-19 stressors, anxiety, and depression in the acute phase of the pandemic: a population-based study in Hong Kong

12 February 2021

EClinicalMedicine: Clinical outcomes of different therapeutic options for COVID-19 in two Chinese case cohorts: A propensity-score analysis

05 February 2021

International Journal of Environmental Research and Public Health: Impact of COVID-19 on Child Maltreatment: Income Instability and Parenting Issues

04 February 2021

The Lancet Public Health: Comparative cost-effectiveness of SARS-CoV-2 testing strategies in the USA: a modelling study

Emerging Microbes & Infections: Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection

30 January 2021

Clinical Infectious Diseases: Absence of vaccine-enhanced disease with unexpected positive protection against SARS-CoV-2 by inactivated vaccine given within three days of virus challenge in Syrian hamster model

Pharmacological Research: Anticoagulant or antiplatelet use and severe COVID-19 disease: A propensity score-matched territory-wide study

14 January 2021

Clinical Ophthalmology: Aerosolization and Fluid Spillage During Phacoemulsification in Human Subjects

08 January 2021

Nature Communications: Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

07 January 2021

Eurosurveillance: Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

06 January 2021

Clinical Infectious Diseases: Changing disparities in COVID-19 burden in the ethnically homogeneous population of Hong Kong through pandemic waves: an observational study

04 January 2021

Nature Communications: Neutralizing antibody titres in SARS-CoV-2 infections

The Journal of Infectious Diseases: Tropism of SARS-CoV-2, SARS-CoV and influenza virus in canine tissue explants

Influenza and Other Respiratory Viruses: Public perception and performance of different sampling approaches for the diagnosis of COVID‐19

22 December 2020

International Journal of Infectious Diseases: Transmission dynamics of the COVID-19 epidemics in England

18 December 2020

BMC Family Practice: Fighting against COVID-19: preparedness and implications on clinical practice in primary care in Shenzhen, China

17 December 2020

Journal of Diabetes Investigation: Is metformin a miracle or a menace in COVID‐19 patients with type 2 diabetes?

15 December 2020

The Canadian Journal of Psychiatry: Mental Health Risks after Repeated Exposure to Multiple Stressful Events during Ongoing Social Unrest and Pandemic in Hong Kong: The Role of Rumination

11 December 2020

Vaccines: Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine

09 December 2020

Eurosurveillance: Face masks and COVID-19: don’t let perfect be the enemy of good

07 December 2020

The Lancet Public Health: Effect of internationally imported cases on internal spread of COVID-19: a mathematical modelling study

Infection Control & Hospital Epidemiology: Infection control challenges in setting up community isolation and treatment facilities for patients with coronavirus disease 2019 (COVID-19): implementation of directly-observed environmental disinfection

The Asia-Pacific Journal of Ophthalmology: Patient Masking and Slit-Lamp Breath Shield for Prevention of Droplet Transmission During Slit-Lamp Examination

04 December 2020

Emerging Microbes & Infections: COVID-19 in children across three Asian cosmopolitan regions

01 December 2020

The Lancet Public Health: The epidemiology of population mental wellbeing in China

25 November 2020

Cell Death Discovery: SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?

23 November 2020

Virology Journal: Evaluation on the use of Nanopore sequencing for direct characterization of coronaviruses from respiratory specimens, and a study on emerging missense mutations in partial RdRP gene of SARS-CoV-2

Frontiers in Psychiatry: Mental Health Impacts of the COVID-19 Pandemic on International University Students, Related Stressors, and Coping Strategies

18 November 2020

Emerging Microbes & Infections: Loss of orf3b in the circulating SARS-CoV-2 strains

17 November 2020

European Child & Adolescent Psychiatry: Vulnerability and resilience in children during the COVID-19 pandemic
Link to Press Release

13 November 2020

International Journal of Environmental Research and Public Health: Impact of COVID-19 on the Hong Kong Youth Quitline Service and Quitting Behaviors of Its Users

12 November 2020

Emerging Microbes & Infections: Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target

11 November 2020

Proceedings of the National Academy of Sciences of the United States of America: Network interventions for managing the COVID-19 pandemic and sustaining economy

07 November 2020

The Lancet: Early triple antiviral therapy for COVID-19 – Authors' reply

05 November 2020

International Journal of Epidemiology: Erratum to: COVID-19 epidemic: disentangling the re-emerging controversy about medical facemasks from an epidemiological perspective

03 November 2020

The Journal of Clinical Endocrinology & Metabolism: Thyroid Dysfunction in Relation to Immune Profile, Disease Status, and Outcome in 191 Patients with COVID-19

02 November 2020

Journal of Clinical Microbiology: Evaluation of a SARS-CoV-2 surrogate virus neutralization test for detection of antibody in human, canine, cat and hamster sera

31 October 2020

Clinical Microbiology and Infection: Intra-host non-synonymous diversity at a neutralizing antibody epitope of SARS-CoV-2 spike protein N-terminal domain

23 October 2020

Circulation Journal: Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Platform to Study SARS-CoV-2 Related Myocardial Injury

The BMJ: Virology, transmission, and pathogenesis of SARS-CoV-2

21 October 2020

Emerging Infectious Diseases: Serologic Responses in Healthy Adult with SARS-CoV-2 Reinfection, Hong Kong, August 2020

20 October 2020

mBio: Accurate Diagnosis of COVID-19 by a Novel Immunogenic Secreted SARS-CoV-2 orf8 Protein

Clinical Infectious Diseases: Different transmission dynamics of COVID-19 and influenza suggest the relative efficiency of isolation/quarantine and social distancing against COVID-19 in China

08 October 2020

BMJ Open: Anxiety levels, precautionary behaviours and public perceptions during the early phase of the COVID-19 outbreak in China: a population-based cross-sectional survey

07 October 2020

Nature Microbiology: Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters

Clinical Chemistry and Laboratory Medicine: IFCC interim guidelines on molecular testing of SARS-CoV-2 infection

Clinical Chemistry and Laboratory Medicine: IFCC interim guidelines on serological testing of antibodies against SARS-CoV-2

Clinical Chemistry and Laboratory Medicine: IFCC interim guidelines on biochemical/hematological monitoring of COVID-19 patients

Journal of Medical Virology: Suppression of SARS‐CoV‐2 infection in ex‐vivo human lung tissues by targeting class III phosphoinositide 3‐kinase

Emerging Microbes & Infections: Short- and potential long-term adverse health outcomes of COVID-19: a rapid review

08 October 2020

BMJ Open: Anxiety levels, precautionary behaviours and public perceptions during the early phase of the COVID-19 outbreak in China: a population-based cross-sectional survey

Asia-Pacific Journal of Ophthalmology: Patient Masking and Slit-Lamp Breath Shield for Prevention of Droplet Transmission During Slit-Lamp Examination

06 October 2020

British Journal of Clinical Pharmacology: Using genetics to understand the role of antihypertensive drugs modulating angiotensin‐converting enzyme in immune function and inflammation

04 October 2020

Transfusion Medicine: Absence of SARS‐CoV‐2 viraemia in a blood donor with COVID‐19 post‐donation

30 September 2020

Cellular and Molecular Gastroenterology and Hepatology: SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19

Emerging Infectious Diseases: SARS-CoV-2 in Quarantined Domestic Cats from COVID-19 Households or Close Contacts, Hong Kong, China

29 September 2020

MedEdPublish: COVID-19 – A Covert Catalyst for Pedagogical Stocktake and Transformation: Perspectives of a Global Hub

24 September 2020

The Lancet: Lessons learnt from easing COVID-19 restrictions: an analysis of countries and regions in Asia Pacific and Europe

23 September 2020

Clinical Infectious Diseases: Serum antibody profile of a patient with COVID-19 reinfection

21 September 2020

The Lancet: What can we expect from first-generation COVID-19 vaccines?

Current Opinion in HIV and AIDS: The Coronavirus Disease 2019 pandemic - how does it spread and how do we stop it?

Cell Reports Medicine: Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters

Epilepsy & Behavior: Impact of COVID-19 on seizure-related emergency attendances and hospital admissions — A territory-wide observational study

20 September 2020

Nephrology: Case of “relapsing” COVID‐19 in a kidney transplant recipient

18 September 2020

Emerging Infectious Diseases: In-Flight Transmission of Severe Acute Respiratory Syndrome Coronavirus 2

17 September 2020

Nature Medicine: Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong
Link to press release

Infection: Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms

Emerging Microbes & Infections: Short- and Potential Long-term Adverse Health Outcomes of COVID-19: A Rapid Review

Eurosurveillance: Letter to the Editor: COVID-19 cases among school-aged children and school-based measures in Hong Kong, July 2020

15 September 2020

International Journal of Infectious Diseases: Development and Validation of Risk Prediction Models for COVID-19 Positivity in a Hospital Setting

International Journal of Infectious Diseases: Mental health crisis under COVID-19 pandemic in Hong Kong, China

14 September 2020

International Journal of Environmental Research and Public Health: Social Distancing Compliance under COVID-19 Pandemic and Mental Health Impacts: A Population-Based Study

12 September 2020

Clinical Biochemistry: Staff rostering, split team arrangement, social distancing (physical distancing) and use of personal protective equipment to minimize risk of workplace transmission during the COVID-19 pandemic: A simulation study

11 September 2020

Emerging Infectious Diseases: Early Insights from Statistical and Mathematical Modeling of Key Epidemiologic Parameters of COVID-19

Epidemiology & Infection: Ecologic association between influenza and COVID-19 mortality rates in European countries

09 September 2020

International Journal of Molecular Sciences: Improved Detection of Antibodies against SARS-CoV-2 by Microsphere-Based Antibody Assay

07 September 2020

East Asian Archives of Psychiatry: Suicidal Risk in Older Patients with Depression During COVID-19 Pandemic: a Case-Control Study

28 August 2020

JACC Cardiovascular Imaging: Recovered COVID-19 Patients Show Ongoing Subclinical Myocarditis as Revealed by Cardiac Magnetic Resonance Imaging

Science Advances: Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

25 August 2020

Clinical Infectious Diseases: COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing

Nature Communications: A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

Influenza and Other Respiratory Viruses: Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2

Clinical Chemistry: The Cause of Severe Acute Respiratory Syndrome: What Did We Learn from It?

17 August 2020

Nature Immunology: ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection
Link to press release

Infection Control & Hospital Epidemiology: Absence of nosocomial influenza and respiratory syncytial virus infection in the coronavirus disease 2019 (COVID-19) era: implication of universal masking in hospitals

Nature Medicine: Reply to: Is presymptomatic spread a major contributor to COVID-19 transmission?

14 August 2020

Science Advances: Viruses harness YxxØ motif to interact with host AP2M1 for replication: a vulnerable broad-spectrum antiviral target

12 August 2020

EClinicalMedicine: Using the COVID-19 to influenza ratio to estimate early pandemic spread in Wuhan, China and Seattle, US

11 August 2020

Science: Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

07 August 2020

Journal of Clinical Pathology: COVID-19 salivary signature: diagnostic and research opportunities

International Journal of Molecular Sciences: Development and Evaluation of Novel and Highly Sensitive Single-Tube Nested Real-Time RT-PCR Assays for SARS-CoV-2 Detection

05 August 2020

Clinical Infectious Diseases: Unique SARS-CoV-2 clusters causing a large COVID-19 outbreak in Hong Kong

04 August 2020

Cell Research: SARS-CoV-2 infects human neural progenitor cells and brain organoids
Link to press release

Emerging Infectious Diseases: SARS-CoV-2 Virus Culture and Subgenomic RNA for Respiratory Specimens from Patients with Mild Coronavirus Disease

03 August 2020

Immunity: Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

28 July 2020

International Journal of Molecular Sciences: A Rapid, Simple, Inexpensive, and Mobile Colorimetric Assay COVID-19-LAMP for Mass On-Site Screening of COVID-19

28 July 2020

Nature Microbiology: Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

22 July 2020

Journal of Medical Internet Research: Impact of National Containment Measures on Decelerating the Increase in Daily New Cases of COVID-19 in 54 Countries and 4 Epicenters of the Pandemic: Comparative Observational Study

BMJ Open: Artificial intelligence mobile health platform for early detection of COVID-19 in quarantine subjects using a wearable biosensor: protocol for a randomised controlled trial

21 July 2020

Science: Serial interval of SARS-CoV-2 was shortened over time by nonpharmaceutical interventions
Link to press release

Journal of Neuroimmune Pharmacology: The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections

15 July 2020

Clinical Infectious Diseases: SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters

Clinical Infectious Diseases: SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters

13 July 2020

ACS Applied Materials & Interfaces: A Surface Coating that Rapidly Inactivates SARS-CoV-2

08 July 2020

Journal of Hospital Infection: Factors affecting stability and infectivity of SARS-CoV-2

03 July 2020

Emerging Microbes & Infections: High neutralizing antibody titer in intensive care unit patients with COVID-19

02 July 2020

Clinical Infectious Diseases: Importance of face masks for COVID-19 – a call for effective public education

01 July 2020

Cell Research: Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients

The Lancet Respiratory Medicine: SARS-CoV-2 infection in conjunctival tissue – Authors' reply

24 June 2020

Influenza and Other Respiratory Viruses: SARS‐CoV‐2 environmental contamination associated with persistently infected COVID‐19 patients 

23 June 2020

Journal of Clinical Virology: Evaluation of simple nucleic acid extraction methods for the detection of SARS-CoV-2 in nasopharyngeal and saliva specimens during global shortage of extraction kits 

21 June 2020

Journal of Infectious Diseases: Attenuated interferon and pro-inflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation 

20 June 2020

Emerging Microbes & Infections: SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists 

18 June 2020

Clinical Infectious Diseases: Reconstruction of Transmission Pairs for Novel Coronavirus Disease 2019 (COVID-19) in Mainland China: Estimation of Super-spreading Events, Serial Interval, and Hazard of Infection 

12 June 2020

The Lancet Infectious Diseases: SARS-CoV-2 shedding and seroconversion among passengers quarantined after disembarking a cruise ship: a case series 

11 June 2020

Hong Kong Medical Journal: Responding to COVID-19 in Hong Kong 

10 June 2020

Viruses: Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19) 

08 June 2020

Infection Control & Hospital Epidemiology: Air and environmental sampling for SARS-CoV-2 around hospitalized patients with coronavirus disease 2019 (COVID-19) 

PLOS Pathogens: Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus 

07 June 2020

Open Forum Infectious Diseases: Early Morning Versus Spot Posterior Oropharyngeal Saliva for Diagnosis of SARS-CoV-2 Infection: Implication of Timing of Specimen Collection for Community-wide Screening 

05 June 2020

Open Forum Infectious Diseases: Olfactory dysfunction in COVID-19 patients: observational cohort study and systematic review

Journal of Medical Virology: Identification of nsp1 gene as the target of SARS‐CoV‐2 real‐time RT‐PCR using nanopore whole genome sequencing

04 June 2020

Psycho-Oncology: Psychological distress during the 2019 Coronavirus Disease (COVID ‐19) pandemic among cancer survivors and healthy controls

03 June 2020

The Lancet Microbe: Seroprevalence of SARS-CoV-2 in Hong Kong and in residents evacuated from Hubei province, China: a multicohort study

02 June 2020

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control Releases Superspreading and Latest Epidemiologic Update of COVID-19
Link to press release

Emerging Infectious Diseases: Effect of Nonpharmaceutical Interventions on Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, South Korea, 2020

01 June 2020

Pediatric Pulmonology: Overview: The history and pediatric perspectives of severe acute respiratory syndromes: Novel or just like SARS

Journal of Clinical Microbiology: Clinical performance of the Luminex NxTAG CoV Extended Panel for SARS-CoV-2 detection in nasopharyngeal specimens of COVID-19 patients in Hong Kong

30 May 2020

Clinical Infectious Diseases: Surgical mask partition reduces the risk of non-contact transmission in a golden Syrian hamster model for Coronavirus Disease 2019 (COVID-19)

29 May 2020

Graefe's Archive for Clinical and Experimental Ophthalmology: Tele-ophthalmology amid COVID-19 pandemic—Hong Kong experience

28 May 2020

Pharmacological Research: Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

Gastroenterology: Association between famotidine use and COVID-19 severity in Hong Kong: a territory-wide study

27 May 2020

Journal of Clinical Virology: Evaluation of the commercially available LightMix® Modular E-gene kit using clinical and proficiency testing specimens for SARS-CoV-2 detection

Emerging Microbes & Infections: Evaluating the use of posterior oropharyngeal saliva in a point-of-care assay for the detection of SARS-CoV-2

24 May 2020

American Journal of Infection Control: Absence of nosocomial transmission of coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in the pre-pandemic phase in Hong Kong

21 May 2020

JAMA Network Open: Estimating Coronavirus Disease 2019 Infection Risk in Health Care Workers

17 May 2020

Cell Reports: Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

15 May 2020

Journal of Hospital Infection: Is it possible to achieve 100 percent hand hygiene compliance during the COVID-19 pandemic?

Clinical Infectious Diseases: Case fatality risk of the first pandemic wave of novel coronavirus disease 2019 (COVID-19) in China

14 May 2020

Nature: Pathogenesis and transmission of SARS-CoV-2 in golden hamsters
Link to press release

Nature: Infection of dogs with SARS-CoV-2

The Lancet: Global coordination on cross-border travel and trade measures crucial to COVID-19 response

Virus Evolution: Multivariate analyses of codon usage of SARS-CoV-2 and other betacoronaviruses

Cell: Structural and Functional Basis of SARS-CoV-2 Entryby Using Human ACE2

13 May 2020

Nature Medicine: Infection of bat and human intestinal organoids by SARS-CoV-2 

12 May 2020

JMIR Mental Health: Mental Health, Risk Factors, and Social Media Use During the COVID-19 Epidemic and Cordon Sanitaire Among the Community and Health Professionals in Wuhan, China: Cross-Sectional Survey

08 May 2020

The Lancet: Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

07 May 2020

The Lancet Respiratory Medicine: Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures
Link to press release

06 May 2020

Nature Reviews Physics: Modelling COVID-19

04 May 2020

The BMJ: Monitoring respiratory infections in covid-19 epidemics

Eye: Diabetic retinopathy screening during the coronavirus disease 2019 pandemic

Emerging Microbes & Infections: Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

01 May 2020

Journal of Cataract and Refractive Surgery: The case for continuing elective cataract surgery during the COVID-19 pandemic

25 April 2020

Chinese Journal of Biotechnology (生物工程学报): Diagnosis, Treatment, Control and Prevention of SARS-CoV-2 and Coronavirus Disease 2019: Back to the Future (2019新型冠状病毒及其诊疗与防控:回顾与展望)

23 April 2020

Medical Education: Ophthalmic clinical skills teaching in the time of COVID‐19: A crisis and opportunity

Journal of Infection: The role of community-wide wearing of face mask for control of coronavirus disease 2019 (COVID-19) epidemic due to SARS-CoV-2

Eurosurveillance: Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020

22 April 2020

Clinical Infectious Diseases: A case series of children with Coronavirus Disease 2019: what have we learned?

21 April 2020

The Lancet Public Health: Effect of changing case definitions for COVID-19 on the epidemic curve and transmission parameters in mainland China: a modelling study

Eye: Maintenance of ophthalmic specialist out-patient service during the COVID-19 outbreak: The University of Hong Kong experience

17 April 2020

The Lancet Public Health: Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study
Link to press release

15 April 2020

HKUMed: HKUMed research shows that stroke patients are presenting to hospitals one hour later during COVID-19, potentially jeopardising the patients’ eligibility for treatments and affecting the outcome
Link to press release

Nature Medicine: Temporal dynamics in viral shedding and transmissibility of COVID-19 

The New England Journal of Medicine: From a Sprint to a Marathon in Hong Kong

09 April 2020

Clinical Infectious Diseases: Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

08 April 2020

The Lancet: First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment

International Journal of Molecular Sciences: Development of a Novel, Genome Subtraction-Derived, SARS-CoV-2-Specific COVID-19-nsp2 Real-Time RT-PCR Assay and Its Evaluation Using Clinical Specimens

Journal of Hospital Infection: Disinfection of N95 respirators by ionized hydrogen peroxide during pandemic coronavirus disease 2019 (COVID-19) due to SARS-CoV-2

03 April 2020

Disaster Medicine and Public Health Preparedness: Limited early warnings and public attention to COVID-19 in China, January-February, 2020: a longitudinal cohort of randomly sampled Weibo users

Gastroenterology: Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis

Nature Medicine: Respiratory virus shedding in exhaled breath and efficacy of face masks

The BMJ: Covid-19: how a virus is turning the world upside down

Antiviral Research: Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

02 April 2020

The Lancet Microbe: Stability of SARS-CoV-2 in different environmental conditions

31 March 2020

International Journal of Epidemiology: COVID-19 epidemic: disentangling the re-emerging controversy about medical facemasks from an epidemiological perspective

26 March 2020

Nature: Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins

Clinical Infectious Diseases: Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility 

The New England Journal of Medicine: Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

23 March 2020

The Lancet Infectious Diseases: Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study

20 March 2020

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases real-time situation report by the instantaneous effective reproductive number (Rt) of COVID-19
Link to presentation here

The Lancet Respiratory Medicine: Rational use of face masks in the COVID-19 pandemic

JAMA Otolaryngology – Head & Neck Surgery: Practical Aspects of Otolaryngologic Clinical Services During the 2019 Novel Coronavirus Epidemic: An Experience in Hong Kong

19 March 2020

The Lancet: Viral dynamics in mild and severe cases of COVID-19

Nature Medicine: Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China

Emerging Infectious Diseases: Serial Interval of COVID-19 among Publicly Reported Confirmed Cases

16 March 2020

Cell & Bioscience: SARS-CoV-2 and COVID-19: The most important research questions

14 March 2020

Emerging Microbes & Infections: A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses

12 March 2020

The New England Journal of Medicine: Detection of Covid-19 in Children in Early January 2020 in Wuhan, China

Microbiology Resource Announcements: Complete Genome Sequence of a 2019 Novel Coronavirus (SARS-CoV-2) Strain Isolated in Nepal

06 March 2020

The Lancet: COVID-19: the gendered impacts of the outbreak 

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases case fatality risk of COVID-19
Link to presentation

The Lancet: Are high-performing health systems resilient against the COVID-19 epidemic?

The Lancet: SARS-CoV-2 is an appropriate name for the new coronavirus

05 March 2020

Infection Control & Hospital Epidemiology: Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong

04 March 2020

Journal of Clinical Microbiology: Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens

02 March 2020

Nature Microbiology: The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

28 February 2020

The New England Journal of MedicineClinical Characteristics of Coronavirus Disease 2019 in China

27 February 2020

Nature Medicine: Emergence of a novel human coronavirus threatening human health

British Journal of Anaesthesia: Outbreak of a new coronavirus: what anaesthetists should know

26 February 2020

Clinical Chemistry: The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception  

24 February 2020

The Lancet Infectious Diseases: COVID-19 pneumonia: what has CT taught us?  

The Lancet Infectious Diseases: Viral load of SARS-CoV-2 in clinical samples

21 February 2020

The Journal of the American Medical Association: Presumed Asymptomatic Carrier Transmission of COVID-19

20 February 2020

HKUMed: Pseudo-colour scanning electron micrograph of SARS-CoV-2 grown in culture from a patient isolate. After 24 hours in culture there are large numbers of orange viral particles on the surface of the cell (blue). Image courtesy of LKS Faculty of Medicine,  Department of Electrical and Electronic Engineering (K.Tsia, K.Lee and Q.Lai), and Electron Microscopy Unit, The University of Hong Kong 
Link to high-resolution image

The Lancet Digital Health: Crowdsourcing data to mitigate epidemics 

19 February 2020

The New England Journal of Medicine: SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients - 

13 February 2020

Emerging Infectious Diseases: Risk for Transportation of 2019 Novel Coronavirus Disease from Wuhan to Other Cities in China 

Eurosurveillance: Epidemiological research priorities for public health control of the ongoing global novel coronavirus (2019-nCoV) outbreak

12 February 2020

Clinical Infectious Diseases: Consistent Detection of 2019 Novel Coronavirus in Saliva

10 February 2020

The Lancet Infectious Diseases: The first 2019 novel coronavirus case in Nepal

06 February 2020

Emerging Infectious Diseases: Nonpharmaceutical Measures for Pandemic Influenza in Nonhealthcare Settings — Social Distancing Measures 

HKUMed: Thin-section electron micrographs of the 2019 novel coronavirus grown in cells at The University of Hong Kong. The image shows part of a virus infected cell grown in culture with multiple virus particles being released from the cell surface. Each infected cell produces thousands of new infectious virus particles which can go on to infect new cells. Image credit: John Nicholls, Leo Poon and Malik Peiris, The University of Hong Kong 
Link to high-resolution image

05 February 2020

HKUMed: Short Video of the new Novel Coronavirus Growing in Culture

03 February 2020

The BMJ Opinion: We need new forms of governance to better manage our response to pandemics -

31 January 2020

Clinical Chemistry: Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia - 

The BMJ: Response to the emerging novel coronavirus outbreak 

The Lancet: Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study

29 January 2020

The New England Journal of Medicine: Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

27 January 2020

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases real-time nowcast on the likely extent of the Wuhan coronavirus outbreak, and forecasts domestic and international spread – UPDATE
Link to presentation here

24 January 2020

The Lancet: A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

23 January 2020

Eurosurveillance: Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020

22 January 2020

Eurosurveillance: Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR 

Eurosurveillance: Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020

21 January 2020

HKUMed: Statistical Tool for Predictive Analytics to Provide Real Time Estimates 

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases real-time nowcast on the likely extent of the Wuhan coronavirus outbreak, domestic and international spread with the forecast for chunyun
Link to presentation here

18 January 2020

Journal of Hospital Infection: Preparedness and proactive infection control measures against the emerging novel coronavirus in China

16 January 2020

WHO: Detection of 2019 novel coronavirus (2019-nCoV) in suspected human cases by RT-PCR