Publications

Publications involving the use of equipment in Faculty Core Facility (from Jan, 2011 to June 2012)

Faculty of Medicine

Department of Anatomy

	Title	Journal	Publication Date
1	Temporal relationships of autophagy and neuronal apoptosis in low molecular weight β-amyloid peptide neurotoxicity	J. Cell. Mol. Med	2011/02
2	Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in Alzheimer’s disease pathogenesis.	J Alz Dis	2012/02
3	Overexpression of a Novel Activator of PAK4, the CDK5 Kinase-Associated Protein CDK5RAP3, Promotes Hepatocellular Carcinoma Metastasis.	Cancer Res.	2011/04
4	AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells	Cancer Res	2012/06
5	Critical roles of Ring Finger Protein RNF8 in replication stress responses	J Biol Chem	2011/05
6	Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation.	Nucleic Acids Res	2011/09
8	Ring Finger Protein RNF169 antagonises the ubiquitin-dependent signaling cascade at sites of DNA damage.	J Biol Chem	2012/06
9	Protection and Restoration of cone photoreceptors in retinitis pigmentosa by a novel multifunctional drug.	HKU Sixth International Symposium on Healthy Aging,	2011/03
10	Remodeling of cone bipolar cells in the mouse model of retinitis pigmentosa	Association for Research in Vision and Ophthalmology Annual Meeting, USA,	2011/05
11	Long-term In vivo Imaging and Measurement of Dendritic Shrinkage of Retinal Ganglion	Cells. IOVS	2011/03
12	Y-like Retinal Ganglion Cells Innervate the Dorsal Raphe Nucleus in the Mongolian Gerbil (Meriones unguiculatus).	PLoS ONE	2011/04
13	Soluble NgR Fusion Protein Modulates the Proliferation of Neural Progenitor Cells via the Notfch Pathway.	Neurochem Res	2011/12
14	Loss of ΔNp63α promotes mitotic exit in epithelial cells	FEBS Lett.	2011/09
15	Optimal time point for neuronal generation of transplanted neural progenitor cells in injured spinal cord following root avulsion.	Cell Transplantation. Cell Transplant.	2011/02

Department of Biochemistry

1	Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells.	Molecular Cancer	2011/09
2	Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide.	Proc Natl Acad Sci	2011/02
3	The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response.	Cell Host Microbe.	2011/04
4	SWI/SNF component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during secondary heart field development.	J. Biol. Chem., epublication ahead of print on	2012/07
5	Interplay between EPS8 and FOXM1 in carcinogenesis.	13th IUBMB Conference & 3rd National Meeting of the Signal Transduction	2011/10
6	sPDZD2, a novel modulator in Hedgehog signaling.	Japan Society of Developmental Biology 2011	2011/03
7	EPS8 and FOXM1 - Do they mesh to promote carcinogenesis?	16th Research Postgraduate Symposium	2011/12
8	Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice.	PNAS	2011/07

Deptment of Clinical Oncology

1	Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion.	Gut.	2011/04
2	Wnt2 secreted by tumor fibroblasts promotes tumor progression in esophageal cancer via the activation of Wnt/b-catenin signaling pathway.	Gut	2011/06
3	Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis.	Br J Cancer	2011/02
4	Tumor suppressor Dual-Specificity Phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype.	Int J Cancer	2012/01
5	The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.	Cancer Letters	2012/03

Department of Microbiology

1	Infection of immunocompromised human by H9N2 influenza A virus.	J Infect	2011/02
2	Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses.	Antimicrobial Agents and Chemotherapy	2011/04
3	Differences in the antibody responses between individuals with natural infection of and those vaccinated against pandemic H1N1 2009 influenza.	Clinical Vaccine Immunology	2011/05
4	Structural basis and sequence co-evolution analysis of the hemagglutinini protein of the pandemic influenza A/H1N1 virus.	Experimental Biology and Medicine	2011/08
5	High incidence of severe influenza among individuals aged over 50 years.	Clin Vaccine Immunol	2011/11
6	Novel reassortment of Eurasian Avian-like and pandemic/2009 influenza viruses in swine: infectious potential to humans.	J Virol	2011/11
7	Two-dimensional antigenic dendrogram and phylogenetic tree of avian influenza virus H5N1.	FEMS Immunol Med Microbiol	2012/03
8	Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats.	PNAS	2012/04

Department of Paediatrics & Adolescent Medicine

1	Subcellular Localization of SUN2 is 1 Regulated by Lamin A and Rab5	PLoS One	2011/05
2	Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-γ- and T-bet-dependent pathway.	European Journal of Immunology	2011/01
3	Th1 or Th1-like regulatory T cells induced by CD40-activated B cells depends on the activation to T cells.	European Journal of Immunology.	2011/01
4	The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a {gamma}{delta} T cell population in humanized mice.	J Exp Med	2011/07
5	Type-1 responses of human Vgamma9Vdelta2 T cells to influenza A viruses.	J Virol	2011/10
6	Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection	J Infect Dis	2012/01
7	Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease	Genes Immun	2012/04
8	Phenotypic and functional characterization of human γδ T cell subsets in response to influenza A viruses.	J Infect Dis	2012/06
9	Tyrosine kinase btk is required for NK cell activation.	J Biol Chem	2012/06

Department of Pathology

1	CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated nanog regulation.	Cell Stem Cell	2011/07
2	CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling	Hepatology	2012/03
3	Caveolin-1 is overexpressed and associated with hepatocellular carcinoma tumorigenesis and metastasis.	J Pathol	2011/11

Department of Pharmacology & Pharmacy

1	HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction.	AIDS.	2011/01
2	Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways.	Journal of Controlled Release	2012/03
3	Non-genomic activation of adenylyl cyclase and protein kinase G by 17β-estradiol in vascular smooth muscle of the rat superior mesenteric artery.	Pharmacol Res	2011/11
4	Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries.	Am J Physiol Heart Circ Physiol	2011/12

Department of Physiology

Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose.

J Biol Chem

2011/06

Department of Obstetrics and Gynaecology

1	Sperm-borne microRNA-34c is required for the first cleavage division in mouse.	PNAS	2012/01
2	miR-135A regulates preimplantation embryo development through down-regulation of E3 Ubiquitin Ligase Seven In Absentia Homolog 1A (SIAH1A) expression	PLoS One	2011/11

Department of surgery

1	A novel mutation in the start codon of the endothelin B receptor leads to Waadenburg-Hirschsprung disease.	16th Research Postgraduate Symposium, HKU	2011/12
2	Overexpression of matrix metalloproteinase- (MMP-12) correlates with poor prognosis of hepatocellular carcinoma.	Eur J Cancer	2011/10
3	The role of proline rich tyrosine kinase 2 (Pyk2) on cisplatin resistance in hepatocellular carcinoma.	Plos One	2011/11
4	Hedgehog-Notch induced premature gliogenesis represents a new disease mechanism for Hirschsprung’s disease.	J Clin Invest	2011/09
5	Characterization of the epigenetic modification patterns of pluripotent stem cell genes in human cancers .	AACR Conference: Stem Cells, Development, and Cancer.	2011/03

School of Chinese Medicine

1	Ginkgo biloba extract (EGb 761) prevents apoptosis in hypoxia-reoxygenated cardiomyocytes: involvement of mitochondria-dependent caspase pathway.	Chinese Medicine	2011/02
2	Caveolin-3 Peptide Protects Cardiomyocytes from Apoptotic Cell Death via Preserving Superoxide Dismutase Activity and Inhibiting Caspase-3 Activation under Hypoxia-reoxygenation.	Amer J Biomed Sci	2011/03
3	Caveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions.	Biochem Biophys Res Commun	2011/04
4	Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway.	PLoS One	2011/08
5	Caveolin-1 inhibits oligodendroglial differentiation of neural stem/progenitor cells through modulating β-catenin expression.	Neurochem Int	2011/08
6	Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury.	Arch Biochem Biophys	2011/10
7	Baicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bHLH family protein expression.	Brain Research	2012/01
8	Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.	Cancer Biology & Therapy	2012/02

Stem Cell and Regenerative Medicine Consortium

1	Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes.	PLoS ONE	2011/11
2	Laser and chemical induced fusion to reverse engineer the physical size of hESC-derived CMs: a nongenetic approach for driven physiological hypertrophy and maturation.	Days of Molecular Medicine, 2011, Hong Kong.	2011/11
3	Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes.	Days of Molecular Medicine, 2011, Hong Kong.	2011/11

HKU-Pasteur Research Center

Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection.

J Virol

2012/02

Faculty of Science

Dept. of Chemistry

1	Luminescent cyclometalated platinum(II) complexes containing N-heterocyclic carbene ligands with potent in vitro and in vivo anti-cancer properties accumulate in cytoplasmic structures of cancer cells.	Chemical Science	2011/01
2	Activation of autophagy of Aggregation-prone ubiquitinated proteins by Timosaponin A-III.	J Biol Chem	2011/07

Faculty of Engineering

Department of Mechanical Engineering

Regulation of migration characteristics of human mesenchynal stem cells (hMSCs) by encapsulation in collagen matrix.

International Society of Stem Cell Research (ISSCR) 9th Annual Meeting,

2011/06