Faculty Core Facility
Address: L6-11, 6/F, Laboratory Block, 21 Sassoon Road, Pokfulam Hong Kong

Tel: 39177557
Fax: 29864297
E-mail: corefac@hku.hk


Publications involving the use of equipment in Faculty Core Facility (from Jan, 2011 to June 2012)

Faculty of Medicine

Department of Anatomy

Title Journal Publication Date
1 Temporal relationships of autophagy and neuronal apoptosis in low molecular weight β-amyloid peptide neurotoxicity J. Cell. Mol. Med 2011/02
2 Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in Alzheimer’s disease pathogenesis. J Alz Dis 2012/02
3 Overexpression of a Novel Activator of PAK4, the CDK5 Kinase-Associated Protein CDK5RAP3, Promotes Hepatocellular Carcinoma Metastasis. Cancer Res. 2011/04
4 AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells  Cancer Res 2012/06
5 Critical roles of Ring Finger Protein RNF8 in replication stress responses J Biol Chem 2011/05
6 Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation. Nucleic Acids Res 2011/09
8 Ring Finger Protein RNF169 antagonises the ubiquitin-dependent signaling cascade at sites of DNA damage.  J Biol Chem 2012/06
9 Protection and Restoration of cone photoreceptors in retinitis pigmentosa by a novel multifunctional drug. HKU Sixth International Symposium on Healthy Aging, 2011/03
10 Remodeling of cone bipolar cells in the mouse model of retinitis pigmentosa Association for Research in Vision and Ophthalmology Annual Meeting, USA, 2011/05
11 Long-term In vivo Imaging and Measurement of Dendritic Shrinkage of Retinal Ganglion Cells. IOVS 2011/03
12 Y-like Retinal Ganglion Cells Innervate the Dorsal Raphe Nucleus in the Mongolian Gerbil (Meriones unguiculatus). PLoS ONE 2011/04
13 Soluble NgR Fusion Protein Modulates the Proliferation of Neural Progenitor Cells via the Notfch Pathway. Neurochem Res 2011/12
14 Loss of ΔNp63α promotes mitotic exit in epithelial cells FEBS Lett. 2011/09
15 Optimal time point for neuronal generation of transplanted neural progenitor cells in injured spinal cord following root avulsion. Cell Transplantation. Cell Transplant. 2011/02


Department of Biochemistry

1 Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Molecular Cancer 2011/09
2 Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide. Proc Natl Acad Sci 2011/02
3 The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response. Cell Host Microbe. 2011/04
4 SWI/SNF component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during secondary heart field development. J. Biol. Chem., epublication ahead of print on 2012/07
5 Interplay between EPS8 and FOXM1 in carcinogenesis. 13th IUBMB Conference & 3rd National Meeting of the Signal Transduction 2011/10
6 sPDZD2, a novel modulator in Hedgehog signaling. Japan Society of Developmental Biology 2011 2011/03
7 EPS8 and FOXM1 - Do they mesh to promote carcinogenesis? 16th Research Postgraduate Symposium 2011/12
8 Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. PNAS 2011/07


Deptment of Clinical Oncology

1 Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion. Gut. 2011/04
2 Wnt2 secreted by tumor fibroblasts promotes tumor progression in esophageal cancer via the activation of Wnt/b-catenin signaling pathway. Gut 2011/06
3 Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis. Br J Cancer 2011/02
4 Tumor suppressor Dual-Specificity Phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype. Int J Cancer 2012/01
5 The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma. Cancer Letters 2012/03


Department of Microbiology

1 Infection of immunocompromised human by H9N2 influenza A virus. J Infect 2011/02
2 Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses. Antimicrobial Agents and Chemotherapy 2011/04
3 Differences in the antibody responses between individuals with natural infection of and those vaccinated against pandemic H1N1 2009 influenza. Clinical Vaccine Immunology 2011/05
4 Structural basis and sequence co-evolution analysis of the hemagglutinini protein of the pandemic influenza A/H1N1 virus. Experimental Biology and Medicine 2011/08
5 High incidence of severe influenza among individuals aged over 50 years. Clin Vaccine Immunol 2011/11
6 Novel reassortment of Eurasian Avian-like and pandemic/2009 influenza viruses in swine: infectious potential to humans. J Virol 2011/11
7 Two-dimensional antigenic dendrogram and phylogenetic tree of avian influenza virus H5N1. FEMS Immunol Med Microbiol 2012/03
8 Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats. PNAS 2012/04


Department of Paediatrics & Adolescent Medicine

1 Subcellular Localization of SUN2 is 1 Regulated by Lamin A and Rab5 PLoS One 2011/05
2 Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-γ- and T-bet-dependent pathway. European Journal of Immunology 2011/01
3 Th1 or Th1-like regulatory T cells induced by CD40-activated B cells depends on the activation to T cells. European Journal of Immunology. 2011/01
4 The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a {gamma}{delta} T cell population in humanized mice. J Exp Med 2011/07
5 Type-1 responses of human Vgamma9Vdelta2 T cells to influenza A viruses. J Virol 2011/10
6 Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection J Infect Dis 2012/01
7 Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease Genes Immun 2012/04
8 Phenotypic and functional characterization of human γδ T cell subsets in response to influenza A viruses. J Infect Dis 2012/06
9 Tyrosine kinase btk is required for NK cell activation. J Biol Chem 2012/06


Department of Pathology

1 CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated nanog regulation. Cell Stem Cell 2011/07
2 CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling Hepatology 2012/03
3 Caveolin-1 is overexpressed and associated with hepatocellular carcinoma tumorigenesis and metastasis. J Pathol 2011/11


Department of Pharmacology & Pharmacy

1 HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction. AIDS. 2011/01
2 Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways. Journal of Controlled Release 2012/03
3 Non-genomic activation of adenylyl cyclase and protein kinase G by 17β-estradiol in vascular smooth muscle of the rat superior mesenteric artery. Pharmacol Res 2011/11
4 Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries. Am J Physiol Heart Circ Physiol 2011/12


Department of Physiology

1 Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose. J Biol Chem 2011/06


Department of Obstetrics and Gynaecology

1 Sperm-borne microRNA-34c is required for the first cleavage division in mouse. PNAS 2012/01
2 miR-135A regulates preimplantation embryo development through down-regulation of E3 Ubiquitin Ligase Seven In Absentia Homolog 1A (SIAH1A) expression PLoS One 2011/11


Department of surgery

1 A novel mutation in the start codon of the endothelin B receptor leads to Waadenburg-Hirschsprung disease. 16th Research Postgraduate Symposium, HKU 2011/12
2 Overexpression of matrix metalloproteinase- (MMP-12) correlates with poor prognosis of hepatocellular carcinoma. Eur J Cancer 2011/10
3 The role of proline rich tyrosine kinase 2 (Pyk2) on cisplatin resistance in hepatocellular carcinoma. Plos One 2011/11
4 Hedgehog-Notch induced premature gliogenesis represents a new disease mechanism for Hirschsprung’s disease. J Clin Invest 2011/09
5 Characterization of the epigenetic modification patterns of pluripotent stem cell genes in human cancers . AACR Conference: Stem Cells, Development, and Cancer. 2011/03


School of Chinese Medicine

1 Ginkgo biloba extract (EGb 761) prevents apoptosis in hypoxia-reoxygenated cardiomyocytes: involvement of mitochondria-dependent caspase pathway. Chinese Medicine 2011/02
2 Caveolin-3 Peptide Protects Cardiomyocytes from Apoptotic Cell Death via Preserving Superoxide Dismutase Activity and Inhibiting Caspase-3 Activation under Hypoxia-reoxygenation. Amer J Biomed Sci 2011/03
3 Caveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions. Biochem Biophys Res Commun 2011/04
4 Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway. PLoS One 2011/08
5 Caveolin-1 inhibits oligodendroglial differentiation of neural stem/progenitor cells through modulating β-catenin expression. Neurochem Int 2011/08
6 Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury. Arch Biochem Biophys 2011/10
7 Baicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bHLH family protein expression. Brain Research 2012/01
8 Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins. Cancer Biology & Therapy 2012/02


Stem Cell and Regenerative Medicine Consortium

1 Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PLoS ONE 2011/11
2 Laser and chemical induced fusion to reverse engineer the physical size of hESC-derived CMs: a nongenetic approach for driven physiological hypertrophy and maturation. Days of Molecular Medicine, 2011, Hong Kong. 2011/11
3 Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes. Days of Molecular Medicine, 2011, Hong Kong. 2011/11

HKU-Pasteur Research Center

1 Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection. J Virol 2012/02

Faculty of Science

Dept. of Chemistry

1 Luminescent cyclometalated platinum(II) complexes containing N-heterocyclic carbene ligands with potent in vitro and in vivo anti-cancer properties accumulate in cytoplasmic structures of cancer cells. Chemical Science 2011/01
2 Activation of autophagy of Aggregation-prone ubiquitinated proteins by Timosaponin A-III. J Biol Chem 2011/07

Faculty of Engineering

Department of Mechanical Engineering

1 Regulation of migration characteristics of human mesenchynal stem cells (hMSCs) by encapsulation in collagen matrix. International Society of Stem Cell Research (ISSCR) 9th Annual Meeting, 2011/06